Function and dynamics of the Mediator complex: novel insights and new frontiers

被引：5
|
作者：
Morse, Randall H. [1 ,2 ]
机构：
[1] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA
[2] Univ Albany, Dept Biomed Sci, Sch Publ Hlth, Albany, NY 12208 USA
来源：
TRANSCRIPTION-AUSTIN | 2022年 / 13卷 / 1-3期
基金：
美国国家科学基金会;
关键词：
Mediator; transcription; heat shock; saccharomyces cerevisiae; CRISPR; gnomAD; ChIP-seq; RNA-POLYMERASE-II; RESTRICTS TY1 RETROTRANSPOSITION; RIBOSOMAL-PROTEIN GENES; TRANSCRIPTIONAL ACTIVATION; PREINITIATION COMPLEX; REPEAT DOMAIN; TAIL MODULE; HEAT-SHOCK; BINDING; CORE;
D O I：
10.1080/21541264.2022.2085502
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Mediator complex was discovered in the early 1990s as a biochemically fractionated factor from yeast extracts that was necessary for activator-stimulated transcriptional activation to be observed in in vitro transcription assays. The structure of this large, multi-protein complex is now understood in great detail, and novel genetic approaches have provided rich insights into its dynamics during transcriptional activation and the mechanism by which it facilitates activated transcription. Here I review recent findings and unanswered questions regarding Mediator dynamics, the roles of individual subunits, and differences between its function in yeast and metazoan cells.
引用
收藏
页码：39 / 52
页数：14
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