Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

被引：193
|
作者：
Mosnier, LO [1 ]
Griffin, JH [1 ]
机构：
[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
来源：
BIOCHEMICAL JOURNAL | 2003年 / 373卷
关键词：
activated protein C; apoptosis; endothelial cell protein C receptor (EPCR); protease-activated receptor (PAR);
D O I：
10.1042/BJ20030341
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated receptor-1 (PAR-1) and endothelial cell protein C receptor (EPCR) were required for the anti-apoptotic effects of activated protein C.
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页码：65 / 70
页数：6
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