Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues

被引:14
|
作者
Boukezzi, Sarah [1 ,2 ,3 ]
Baunez, Christelle [2 ,3 ]
Rousseau, Pierre-Francois [4 ,5 ]
Warrot, Delphine [6 ]
Silva, Catarina [2 ,3 ,7 ,8 ]
Guyon, Valerie [9 ]
Zendjidjian, Xavier [9 ]
Nicolas, Florian [10 ]
Guedj, Eric [11 ]
Nazarian, Bruno [2 ,3 ]
Trousselard, Marion [12 ,13 ,14 ]
Chaminade, Thierry [2 ,3 ]
Khalfa, Stephanie [4 ]
机构
[1] Harvard Med Sch, Dept Psychiat, Dept Med, Div Womens Hlth, 1620 Tremont St,OBC-3, Boston, MA 02120 USA
[2] Aix Marseille Univ, UMR 7289, Inst Neurosci Timone, Marseille, France
[3] CNRS, Marseille, France
[4] CNRS, UMR 7260, Lab Neurosci Sensorielles & Cognit, Marseille, France
[5] Clin Kerfriden, Clinea, Chateaulin, France
[6] Univ Geneva, Swiss Ctr Affect Sci, Geneva, Switzerland
[7] IUL, ISCTE, Lisbon, Portugal
[8] Hop Salvator, AP HM, Serv Pedopsychiat, Marseille, France
[9] CUMP, AP HM, Marseille, France
[10] Hop Instruct Armees Laveran Marseille, Serv Psychiat, Marseille, France
[11] Aix Marseille Univ, CNRS, Ecole Cent Marseille, UMR 7249,Inst Fresnel, Marseille, France
[12] Inst Rech Biomed Armees, Dept Neurosci & Sci Cognit, Unite Neurophysiol Stress, Bretigny Sur Orge, France
[13] Univ Lorraine, EPSaM, EA 4360, APEMAC, Lorraine, France
[14] Ecole Val Grace, Paris, France
关键词
Posttraumatic Stress Disorder; Reward; Motivation; Imaging; Brain; Psychiatry; MEDIAL PREFRONTAL CORTEX; NEURAL REPRESENTATION; SUBTHALAMIC NUCLEUS; ABNORMAL ACTIVITY; LEARNING SIGNALS; HUMAN NARCOLEPSY; FEAR EXTINCTION; HUMAN STRIATUM; HUMAN AMYGDALA; HUMAN BRAIN;
D O I
10.1016/j.nicl.2019.102073
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
Background: Recent studies suggest that Posttraumatic Stress Disorder (PTSD) might be associated with dysfunctional reward circuitry. However, further research is needed to understand the key role of the reward system in PTSD symptomatology. Methods: Twenty participants with PTSD and 21 Trauma-Exposed matched Controls (TECs) completed the Monetary Incentive Delay (MID) task during an MRI session. Reaction times (RTs) and hit rates were recorded. Brain activity was investigated during the anticipation and the outcome of monetary gains and losses. Results: During the anticipation of monetary loss, PTSD participants had higher RTs than TECs. However, the groups did not differ at the neurofunctional level. During successful avoidance of monetary loss, PTSD patients showed higher activation than TECs in the left caudate nucleus. During the anticipation of monetary gains, no differences in RTs were found between groups. PTSD patients had specific activations in the right amygdala, nucleus accumbens, putamen, and middle frontal gyrus (p < 0.05 family-wise error (FWE)-corrected), while TECs had specific activation in the anterior cingulate cortex. When obtaining monetary gains, PTSD patients had specific activation in the caudate nucleus, while TECs had specific activations in the right hypothalamus, subthalamic nucleus, and left inferior frontal gyrus. Conclusion: For the first time, functional brain activation during both the anticipation and the outcome of monetary rewards is reported altered in PTSD patients. These alterations might be associated with the complex symptomatology of PTSD.
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页数:9
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