The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

被引：7825

作者：

Albert, Marilyn S. ^{[1
]}

DeKosky, Steven T. ^{[2
,16
]}

Dickson, Dennis ^{[3
]}

Dubois, Bruno ^{[4
]}

Feldman, Howard H. ^{[5
]}

Fox, Nick C. ^{[6
]}

Gamst, Anthony ^{[7
]}

Holtzman, David M. ^{[8
,9
]}

Jagust, William J. ^{[10
]}

Petersen, Ronald C. ^{[11
]}

Snyder, Peter J. ^{[12
,13
]}

Carrillo, Maria C. ^{[14
]}

Thies, Bill ^{[14
]}

Phelps, Creighton H. ^{[15
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[3] Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USA

[4] Grp Hosp Pitie Salpetriere, Inst Memory & Alzheimers Dis, INSERM, Unit Cognit Neuroimagerie & Malad Due Cerveau, F-75634 Paris, France

[5] Bristol Myers Squibb Neurosci, Wallingford, CT USA

[6] UCL, Inst Neurol, London, England

[7] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[8] Washington Univ, Dept Neurol, St Louis, MO USA

[9] Washington Univ, Knight Alzheimers Dis Res Ctr, St Louis, MO USA

[10] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[11] Mayo Clin, Dept Neurol, Rochester, MN USA

[12] Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02903 USA

[13] Brown Univ, Dept Neurol, Alpert Med Sch, Providence, RI 02912 USA

[14] Alzheimers Assoc, Chicago, IL USA

[15] NIA, Bethesda, MD 20892 USA

[16] Univ Virginia, Off Dean, Charlottesville, VA USA

来源：

ALZHEIMERS & DEMENTIA | 2011年 / 7卷 / 03期

关键词：

Mild cognitive impairment; AD dementia; Diagnosis; DEMENTIA;

D O I：

10.1016/j.jalz.2011.03.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as mild cognitive impairment due to AD. The workgroup developed the following two sets of criteria: (1) core clinical criteria that could be used by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis, and (2) research criteria that could be used in clinical research settings, including clinical trials. The second set of criteria incorporate the use of biomarkers based on imaging and cerebrospinal fluid measures. The final set of criteria for mild cognitive impairment due to AD has four levels of certainty, depending on the presence and nature of the biomarker findings. Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings. (C) 2011 The Alzheimer's Association. All rights reserved.

引用

页码：270 / 279

页数：10

共 22 条

[1] Structural magnetic resonance imaging in established and prodromal Alzheimer disease: A review [J].

Atiya, M ;

Hyman, BT ;

Albert, MS ;

Killiany, R .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2003, 17 (03) :177-195

[2] Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions [J].

Bennett, DA ;

Schneider, JA ;

Bienias, JL ;

Evans, DA ;

Wilson, RS .

NEUROLOGY, 2005, 64 (05) :834-841

[3] The Genetics of Alzheimer Disease: Back to the Future [J].

Bertram, Lars ;

Lill, Christina M. ;

Tanzi, Rudolph E. .

NEURON, 2010, 68 (02) :270-281

[4] CSF markers for incipient Alzheimer's disease [J].

Blennow, K ;

Hampel, H .

LANCET NEUROLOGY, 2003, 2 (10) :605-613

[5] Research criteria for the diagnosis of Alzheimer"s disease: revising the NINCDS-ADRDA criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Dekosky, Steven T. ;

Barberger-Gateau, Pascale ;

Cummings, Jeffrey ;

Delocourte, Andre ;

Galasko, Douglas ;

Gauthier, Serge ;

Jicha, Gregory ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Solloway, Steven ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2007, 6 (08) :734-746

[6] Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans [J].

Fagan, AM ;

Mintun, MA ;

Mach, RH ;

Lee, SY ;

Dence, CS ;

Shah, AR ;

LaRossa, GN ;

Spinner, ML ;

Klunk, WE ;

Mathis, CA ;

DeKosky, ST ;

Morris, JC ;

Holtzman, DM .

ANNALS OF NEUROLOGY, 2006, 59 (03) :512-519

[7] Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives [J].

Hampel, Harald ;

Frank, Richard ;

Broich, Karl ;

Teipel, Stefan J. ;

Katz, Russell G. ;

Hardy, John ;

Herholz, Karl ;

Bokde, Arun L. W. ;

Jessen, Frank ;

Hoessler, Yvonne C. ;

Sanhai, Wendy R. ;

Zetterberg, Henrik ;

Woodcock, Janet ;

Blennow, Kaj .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (07) :560-574

[8] IIC PiB and structural MRI provide complementary information in imaging of Alzheimers disease and amnestic mild cognitive impairment [J].

Jack, Clifford R., Jr. ;

Lowe, Val J. ;

Senjem, Matthew L. ;

Weigand, Stephen D. ;

Kemp, Bradley J. ;

Shiung, Maria M. ;

Knopman, David S. ;

Boeve, Bradley F. ;

Klunk, William E. ;

Mathis, Chester A. ;

Petersen, Ronald C. .

BRAIN, 2008, 131 :665-680

[9] Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Jack, Clifford R., Jr. ;

Albert, Marilyn S. ;

Knopman, David S. ;

McKhann, Guy M. ;

Sperling, Reisa A. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :257-262

[10]

Jagust William, 2006, Alzheimers Dement, V2, P36, DOI 10.1016/j.jalz.2005.11.002

← 1 2 3 →