Maternal care, hippocampal synaptogenesis and cognitive development in rats

被引：846
作者：
Liu, D
Diorio, J
Day, JC
Francis, DD
Meaney, MJ
机构：
[1] McGill Univ, Dept Psychiat, Douglas Hosp, Res Ctr,Dev Neuroendocrinol Lab, Verdun, PQ H4H 1R3, Canada
[2] McGill Univ, Dept Neurol & Neurosurg, Douglas Hosp, Res Ctr,Dev Neuroendocrinol Lab, Verdun, PQ H4H 1R3, Canada
来源：
NATURE NEUROSCIENCE | 2000年 / 3卷 / 08期
基金：
加拿大自然科学与工程研究理事会; 英国医学研究理事会;
关键词：
D O I：
10.1038/77702
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We report that variations in maternal care in the rat promote hippocampal synaptogenesis and spatial learning and memory through systems known to mediate experience-dependent neural development. Thus, the offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of NMDA receptor subunit and brain-derived neurotrophic factor (BDNF) mRNA, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. A cross-fostering study provided evidence for a direct relationship between maternal behavior and hippocampal development, although not all neonates were equally sensitive to variations in maternal care.
引用
收藏
页码：799 / 806
页数：8
相关论文
共 51 条
[1]   AN ETHOLOGICAL APPROACH TO PERSONALITY-DEVELOPMENT [J].
AINSWORTH, MDS ;
BOWLBY, J .
AMERICAN PSYCHOLOGIST, 1991, 46 (04) :333-341
[2]  
ALBERTS JR, 1989, HDB BEHAV NEUROBIOLO, V9, P1
[3]   BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].
ALDERSON, RF ;
ALTERMAN, AL ;
BARDE, YA ;
LINDSAY, RM .
NEURON, 1990, 5 (03) :297-306
[4]   CONSEQUENCES OF PHYSICAL ABUSE AND NEGLECT IN CHILDREN [J].
AMMERMAN, RT ;
CASSISI, JE ;
HERSEN, M ;
VANHASSELT, VB .
CLINICAL PSYCHOLOGY REVIEW, 1986, 6 (04) :291-310
[5]   Do early-life events permanently alter behavioral and hormonal responses to stressors? [J].
Anisman, H ;
Zaharia, MD ;
Meaney, MJ ;
Merali, Z .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1998, 16 (3-4) :149-164
[6]   DIFFERENTIAL ALTERATION OF VARIOUS CHOLINERGIC MARKERS IN CORTICAL AND SUBCORTICAL REGIONS OF HUMAN-BRAIN IN ALZHEIMERS-DISEASE [J].
ARAUJO, DM ;
LAPCHAK, PA ;
ROBITAILLE, Y ;
GAUTHIER, S ;
QUIRION, R .
JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1914-1923
[7]   Toward a molecular definition of long-term memory storage [J].
Bailey, CH ;
Bartsch, D ;
Kandel, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13445-13452
[8]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[9]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[10]   Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses [J].
Calabresi, P ;
Centonze, D ;
Gubellini, P ;
Pisani, A ;
Bernardi, G .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (09) :3020-3023
123456