In vivo measurement of the brain and skull resistivities using an EIT-based method and the combined analysis of SEF/SEP data

Results of "in vivo", measurements of the skull and brain resistivities are presented for six subjects. Results are obtained using two different methods, based on spherical head models. The first method uses the principles of electrical impedance tomography (EIT) to estimate the equivalent electrical resistivities of brain (rho(brain)), skull (rho(skull)) and skin (rho(skin)) according to [1]. The second one estimates the same parameters through a combined analysis of the evoked somatosensory cortical response, recorded simultaneously using magnetoencephalography (MEG) and electroencephalography (EEG). The EIT results, obtained with the same relative skull thickness (0.05) for all subjects, show a wide variation of the ratio rho(skull)/rho(brain) among subjects (average = 72, SD = 48%). However, the rho(skull)/rho(brain) ratios of the individual subjects are well reproduced by combined analysis of somatosensory evoked fields (SEF) and somatosensory evoked potentials (SEP). These preliminary results suggest that the rho(skull)/rho(brain) variations over subjects cannot be disregarded in the EEG inverse problem (IP) when a spherical model is used. The agreement between EIT and SEF/SEP points to the fact that whatever the source of variability, the proposed EIT-based method <Au: Addition of "method" O.K? appears to have the potential to reduce systematic errors in EEG IP associated to the misspecification of rho(skull)/rho(brain), rho(brain), rho(skull) and rho(skin).