TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

被引：39

作者：

Zixin, Ye ^{[1
,2
,3
,4
]}

Lulu, Chen ^{[5
,6
]}

Xiangchang, Zeng ^{[1
,2
,3
,4
]}

Qing, Fang ^{[5
]}

Binjie, Zheng ^{[1
,2
,3
,4
]}

Chunyang, Luo ^{[6
]}

Tai, Rao ^{[1
,2
,3
,4
]}

Dongsheng, Ouyang ^{[1
,2
,3
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Peoples R China

[2] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha, Peoples R China

[3] Minist Educ, Engn Res Ctr Appl Technol Pharmacogen, Changsha, Peoples R China

[4] Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[5] Hunan Key Lab Bioanal Complex Matrix Samples, Changsha, Peoples R China

[6] Affiliated Hosp Xiangnan Univ, Dept Clin Pharm, Chenzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

trimethylamine N-oxide; chronic kidney disease; gut microbiota; targeted TMAO drugs; mechanism; treatment; TRIMETHYLAMINE-N-OXIDE; FLAVIN-CONTAINING MONOOXYGENASE; L-CARNITINE; RENAL-INSUFFICIENCY; PROBIOTIC SUPPLEMENTATION; MICROBIAL-METABOLISM; SECONDARY PREVENTION; CONTRIBUTES; PROGRESSION; FMO3;

D O I：

10.3389/fphar.2022.929262

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The gut microbiota and its metabolites have become a hotspot of recent research. Trimethylamine N-oxide (TMAO) metabolized by the gut microbiota is closely related to many diseases such as cardiovascular disease, chronic kidney disease, type 2 diabetes, etc. Chronic kidney disease (CKD) is an important contributor to morbidity and mortality from non-communicable diseases. Recently, increasing focus has been put on the role of TMAO in the development and progress of chronic kidney disease. The level of TMAO in patients with chronic kidney disease is significantly increased, and a high level of TMAO deteriorates chronic kidney disease. This article describes the relationship between TMAO and chronic kidney disease and the research progress of drugs targeted TMAO, providing a reference for the development of anti-chronic kidney disease drugs targeted TMAO.

引用

页数：12

共 50 条

[1] Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target
Janeiro, Manuel H.
Ramirez, Maria J.
Milagro, Fermin I.
Alfredo Martinez, J.
Solas, Maite
NUTRIENTS, 2018, 10 (10)
[2] GCGR: novel potential therapeutic target for chronic kidney disease
Hu, Yan
Huang, Hao
Xiang, Rong
SCIENCE CHINA-LIFE SCIENCES, 2024, 67 (07) : 1542 - 1544
[3] GCGR: novel potential therapeutic target for chronic kidney disease
Yan Hu
Hao Huang
Rong Xiang
Science China(Life Sciences), 2024, 67 (07) : 1542 - 1544
[4] Renalase Potential as a Marker and Therapeutic Target in Chronic Kidney Disease
Serban-Feier, Larisa Florina
Cuiban, Elena
Gogosoiu, Elena Bianca
Stepan, Elena
Radulescu, Daniela
BIOMEDICINES, 2024, 12 (08)
[5] Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease
Amaya-Garrido, Ana
Brunet, Manon
Buffin-Meyer, Benedicte
Piedrafita, Alexis
Grzesiak, Lucile
Agbegbo, Ezechiel
Del Bello, Arnaud
Ferrandiz, Ines
Ardeleanu, Serban
Bermudez-Lopez, Marcelino
Fedou, Camille
Camus, Mylene
Burlet-Schiltz, Odile
Massines, Jean
Buleon, Marie
Feuillet, Guylene
Alves, Melinda
Neau, Eric
Casemayou, Audrey
Breuil, Benjamin
Saulnier-Blache, Jean-Sebastien
Denis, Colette
Voelkl, Jakob
Glorieux, Griet
Hobson, Sam
Arefin, Samsul
Rahman, Awahan
Kublickiene, Karolina
Stenvinkel, Peter
Bascands, Jean-Loup
Faguer, Stanislas
Valdivielso, Jose M.
Schanstra, Joost P.
Klein, Julie
SCIENCE TRANSLATIONAL MEDICINE, 2023, 15 (712)
[6] The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease
Yang, Lei
Li, Naijian
Yi, Xinzhu
Wang, Zhang
INTERDISCIPLINARY MEDICINE, 2023, 1 (04):
[7] ZONULIN AS A THERAPEUTIC POTENTIAL BIOMARKER OF ANEMIA IN PATIENTS WITH MULTIPLE MYELOMA AND CHRONIC KIDNEY DISEASE
Woziwodzka, Karolina
Malyszko, Jolanta
Banaszkiewicz, Matgorzata
Koc-Zorawska, Ewa
Dumnicka, Paulina
Krzanowski, Marcin
Batko, Krzysztof
Gatasa, Paulina
Tisonczyk, Joanna
Zorawski, Marcin
Matyszko, Jacek
Drozdz, Ryszard
Kuznieswki, Marek Jan
Krzanowska, Katarzyna
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2020, 35 : 1200 - 1200
[8] Chronic kidney disease: Biomarker diagnosis to therapeutic targets
Wang, Yan-Ni
Ma, Shi-Xing
Chen, Yuan-Yuan
Chen, Lin
Liu, Bao-Li
Liu, Qing-Quan
Zhao, Ying-Yong
CLINICA CHIMICA ACTA, 2019, 499 : 54 - 63
[9] Therapeutic Potential of Photobiomodulation for Chronic Kidney Disease
Bian, Ji
Liebert, Ann
Bicknell, Brian
Chen, Xin-Ming
Huang, Chunling
Pollock, Carol A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (14)
[10] Insulin Resistance as a Therapeutic Target for Chronic Kidney Disease
Teta, Daniel
JOURNAL OF RENAL NUTRITION, 2015, 25 (02) : 226 - 229

← 1 2 3 4 5 →