Iridium-Catalyzed Enantioselective Hydrogenation of Indole and Benzofuran Derivatives

被引：25
|
作者：
Ge, Yao [1 ,2 ]
Wang, Zheng [1 ]
Han, Zhaobin [1 ]
Ding, Kuiling [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 67期
关键词：
asymmetric catalysis; benzofurans; benzothiophene; 1; 1-dioxides; hydrogenation; indoles; iridium; CONVERTING ENZYME-INHIBITORS; DNA-POLYMERASE-BETA; ASYMMETRIC HYDROGENATION; MECHANISTIC INSIGHTS; OXAZOLINE LIGANDS; POTENT; ACID; COMPLEXES; PYRIDINE; (+)-MYRISTININ-A;
D O I：
10.1002/chem.202002532
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enantioselective hydrogenation of a broad spectrum of N-, O-, and S-containing aromatic benzoheterocycles or nonaromatic unsaturated heterocycles has been realized by using an Ir/SpinPHOX (SpinPHOX=spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline) complex as the catalyst, affording an array of the corresponding chiral benzoheterocycles (30 examples) with excellent enantioselectivities (>99 % eein most cases) and turnover numbers up to 500.
引用
收藏
页码：15482 / 15486
页数：5
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