Relief of phospholamban inhibition of the cardiac muscle Ca2+ pump (SERCA2a) raises Vmax by decreasing the Ca2+ affinity of luminal transport sites

被引：0
|
作者：
Froehlich, J
Wilson, GM
Tocchetti, CG
Kass, D
Paolocci, N
机构：
[1] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA
[2] Johns Hopkins Med Inst, Baltimore, MD 21205 USA
来源：
JOURNAL OF GENERAL PHYSIOLOGY | 2005年 / 126卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
124
引用
收藏
页码：54A / 55A
页数：2
相关论文
共 50 条
  • [1] Ca2+ Binding to Site I of the Cardiac Ca2+ Pump (SERCA2a) is Sufficient to Dissociate Phospholamban (PLB)
    Chen, Zhenhui
    Akin, Brandy L.
    Jones, Larry R.
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 142A - 143A
  • [2] Ca2+ affinity, not Vmax, of SERCA2a critically regulates the strength of the heartbeat
    Kirchhefer, U
    Autry, JM
    Begrow, F
    Schmitz, W
    Neumann, J
    Jones, LR
    CIRCULATION, 2000, 102 (18) : 267 - 267
  • [3] Complete dissociation of phospholamban (PLB) from the cardiac Ca pump (SERCA2a) by micromolar Ca2+ and by thapsigargin (TG)
    Chen, ZH
    Jones, L
    BIOPHYSICAL JOURNAL, 2005, 88 (01) : 83A - 83A
  • [4] The Vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin-dependent phosphorylation or by interaction with phospholamban
    Banting Dept. of Medical Research, University of Toronto, Charles H. Best Institute, Toronto, Ont. M5G 1L6, Canada
    不详
    J. Biol. Chem., 24 (14206-14213):
  • [5] Phospholamban inhibits Ca2+ pump oligomerization and intersubunit free energy exchange leading to activation of cardiac muscle SERCA2a
    Mahaney, JE
    Albers, RW
    Kutchai, H
    Froehlich, JP
    NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS, 2003, 986 : 338 - 340
  • [6] Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level
    Vangheluwe, Peter
    Schuermans, Marleen
    Raeymaekers, Luc
    Wuytack, Frank
    CELL CALCIUM, 2007, 42 (03) : 281 - 289
  • [7] The endoplasmic reticulum luminal Ca2+ regulates cardiac Ca2+ pump function
    Bovo, Elisa
    Nikolaienko, Roman
    Kahn, Daniel
    Espinoza-Fonseca, L. Michel
    Zima, Aleksey, V
    PNAS NEXUS, 2025, 4 (02):
  • [8] FUNCTIONAL DIFFERENCE BETWEEN SERCA2A AND SERCA2B CA2+ PUMPS AND THEIR MODULATION BY PHOSPHOLAMBAN
    VERBOOMEN, H
    WUYTACK, F
    DESMEDT, H
    HIMPENS, B
    CASTEELS, R
    BIOCHEMICAL JOURNAL, 1992, 286 : 591 - 595
  • [9] Ca2+ Binding to Site I of the Cardiac Ca2+ Pump Is Sufficient to Dissociate Phospholamban
    Chen, Zhenhui
    Akin, Brandy L.
    Jones, Larry R.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (05) : 3253 - 3260
  • [10] Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump
    Vandecaetsbeek, Ilse
    Trekels, Mieke
    De Maeyer, Marc
    Ceulemans, Hugo
    Lescrinier, Eveline
    Raeymaekers, Luc
    Wuytack, Frank
    Vangheluwe, Peter
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (44) : 18533 - 18538
12345