Synthesis of (±)-γ-Lycorane by Using an Intramolecular Friedel-Crafts Reaction

被引：13

作者：

Bao Nguyen Do Doan ^{[1
]}

Tan, Xin Yi ^{[1
]}

Ang, Chin May ^{[1
]}

Bates, Roderick W. ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 20期

关键词：

heterocycle; pyrrole; Friedel-Crafts; hydrogenation; FORMAL TOTAL-SYNTHESIS; GAMMA-LYCORANE; RADICAL CYCLIZATIONS; 3-SUBSTITUTED PYRROLES; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; (-)-GAMMA-LYCORANE; (+)-GAMMA-LYCORANE; ALKALOIDS; AMIDES;

D O I：

10.1055/s-0036-1589067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of-lycorane has been achieved by employing N-tosylpyrrole as a key building block. The synthesis employs both an intermolecular and an intramolecular Friedel-Crafts reaction, as well as a completely diastereoselective hydrogenation of a late-stage pyrrole intermediate.

引用

页码：4711 / 4716

页数：6

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