Sleep in children and young adults with interstitial and diffuse lung disease

被引:0
|
作者
Thomasson, Diane Abdel-Latif [1 ]
Abou Taam, Rola [2 ]
Berteloot, Laureline [3 ]
Khirani, Sonia [1 ,4 ,5 ]
Griffon, Lucie [1 ,5 ]
Hadchouel, Alice [2 ]
Delacourt, Christophe [2 ]
Fauroux, Brigitte [1 ,5 ]
机构
[1] Hop Necker Enfants Malad, AP HP, Pediat Noninvas Ventilat & Sleep Unit, 149 Rue Sevres, F-75015 Paris, France
[2] Hop Necker Enfants Malad, AP HP, Pediat Pulm Dept, F-75015 Paris, France
[3] Hop Necker Enfants Malad, AP HP, Pediat Radiol, F-75015 Paris, France
[4] ASV Sante, F-92000 Gennevilliers, France
[5] Univ Paris, VIFASOM, F-75004 Paris, France
关键词
Child interstitial and diffuse lung disease; Sleep; Polysomnography; Obstructive sleep apnea; Pulmonary alveolar proteinosis; Surfactant; Diffuse alveolar haemorrhage; INTERMITTENT HYPOXIA; OXYGEN DESATURATION; SYSTEMIC-SCLEROSIS; APNEA; DISORDERS;
D O I
10.1016/j.sleep.2021.01.020
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Obstructive sleep apnea (OSA) is common in adult patients with interstitial lung disease (ILD). The aim of the study was to evaluate the prevalence of OSA and sleep quality in children and young adults with children's interstitial and diffuse lung disease (chILD). Methods: A polysomnography (PSG) was performed in room air in all consecutive patients followed at a national reference centre between June 2018 and September 2019. Clinical and PSG data were collected. Results: The PSG data of 20 patients (12 girls, median age 9 (range 0.5-20) years), were analyzed. Seven (35%) patients had pulmonary alveolar proteinosis (PAP), 5 (25%) a disorder of surfactant metabolism, 3 (15%) diffuse pulmonary hemorrhage, 4 (20%) chILD of unknown etiology and one patient had laryngeal and pulmonary sarcoidosis. The median obstructive apnea-hypnea index (OAHI) was normal at 0 events/hour, with a value > 4 events/hour being observed in 2 young adults: an 18-year-old male with PAP and a vital capacity of 27% predicted who had an OAHI of 10.7 events/hour, and a 20-year-old male with laryngeal and pulmonary sarcoidosis who had positional OSA with an OAHI of 19.5 events/hour. The median total sleep time, sleep efficiency, % of wake after sleep onset, and sleep stages were moderately disturbed. Conclusions: Moderate or severe OSA was not observed in children <18 years with chILD. Mild or moderate OSA was observed in 2 young adults with PAP and sarcoidosis. As opposed to adults, OSA seems uncommon in children with chILD. (C) 2021 Elsevier B.V. All rights reserved.
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页码:23 / 29
页数:7
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