For a long time, monopoly problem attracted more than economics, law, sociology and other scholars in the field of research. In view of the natural monopoly and economic ties, the antitrust laws in the era of knowledge economy, adapt to the society, science and technology and the change of the economic need and take the initiative to change become inevitable. Early antitrust law regulation mode on "monopoly or not" judgment of swing is not qualitative, choose the mode of regulation "ambiguity" status, for scholars to look at the top of the era and the future, to explore the law of antitrust regulation mode. In the study of anti monopoly law, absorbing the essence from the new institutional economics will be a development direction for the regulation of anti monopoly law reform ideas. Ultimately promoting the development of knowledge economy society.