Bipolarins A-H, eight new ophiobolin-type sesterterpenes with antimicrobial activity from fungus Bipolaris sp. TJ403-B1

被引：0
|
作者：
Liu Meng-Ting [1 ]
He Yan [2 ]
Shen Ling [1 ]
Hu Zheng-Xi [1 ]
Zhang Yong-Hui [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Bipolaris sp; Ophiobolins; Sesterterpenes; Antimicrobial activity; PHYTOTOXINS;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Bipolarins A-H (1-8), eight new tetracyclic ophiobolin-type sesterterpenes featuring a rare oxaspiro[4.4]nonane moiety, were isolated from cultures of fungus Bipolaris sp. TJ403-B1. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, electronic circular dichroism and C-13 NMR calculations. Additionally, compound 5 exhibited significant selective antimicrobial activity against Enterococcus faecalis with an MIC value 8 mu g.mL(-1).
引用
收藏
页码：935 / 944
页数：10
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