Synthesis and antibacterial activity of 2-amino-4-(2′-hydroxy-5′-methyl-4′,6′-dibromophen-1′-yl)-6-substituted phenyl pyrimidine derivatives

The reaction of 2'-hydroxy-5'-methyl-4',6'-dibromochalcones with alcoholic solution of guanidine nitrate and-aqueous sodium hydroxide solution gave the corresponding 2-amino-4-(2'-hydroxy-5'-methyl-4',6'-dibromophen-1'-yl)-6-substituted phenyl pyrimidine derivatives. The structure of these compounds has been studied by elemental analysis and spectral method. The antibacterial activity of these compounds has also been investigated.