Chromosome instability and translocation t(11;18) in primary gastric marginal zone B-cell lymphoma of MALT-type

被引：6

作者：

Tibiletti, Maria Grazia ^{[1
]}

Milani, Katia ^{[1
]}

Martin, Vittoria ^{[1
,3
]}

Zucca, Emanuele ^{[4
]}

Motta, Teresio ^{[6
]}

Cortelazzo, Sergio ^{[6
]}

Pinotti, Graziella ^{[2
]}

Mazzucchelli, Luca ^{[3
]}

Pruneri, Giancarlo ^{[7
]}

Martinelli, Giovanni ^{[8
]}

Barbazza, Renzo ^{[9
]}

Capella, Carlo ^{[1
]}

Bertoni, Francesco ^{[5
]}

机构：

[1] Univ Insubria, Osped Circolo, Anat Pathol Unit, I-21100 Varese, Italy

[2] Univ Insubria, Osped Circolo, Oncol Unit, I-21100 Varese, Italy

[3] Ist Cantonale Patol, Locarno, Switzerland

[4] Oncol Inst So Switzerland IOSI, Lymphoma Unit, Bellinzona, Switzerland

[5] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, Bellinzona, Switzerland

[6] Osped Riuniti Bergamo, I-24100 Bergamo, Italy

[7] European Inst Oncol, Div Pathol, Milan, Italy

[8] European Inst Oncol, Dept Haematoncol, Milan, Italy

[9] Osped Civile Feltre, Serv Anat Patol, Feltre, Italy

来源：

HEMATOLOGICAL ONCOLOGY | 2007年 / 25卷 / 04期

关键词：

API2; MALT1; antibiotics; FISH; stomach; MALT; marginal zone;

D O I：

10.1002/hon.825

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognosis for patients with mucosa-associated lymphoid tissue (MALT) lymphomas is good; these tumours have usually an indolent course with overall survival rates that are greater than 80% at 5-year, but some rare cases with histological transformation in aggressive diffuse large cell lymphoma have also been diagnosed. Here, we present cytogenetic results on endoscopic bioptic material of 42 cases of primary gastric extranodal marginal zone B-cell lymphoma (EMZL) using fluorescence in situ hybridization (FISH) approach with API2, MALT1 and centromeric probes for chromosome 3 and 18, and their impact on the clinical outcome. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：184 / 188

页数：5

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