Associations of alveolar bone loss and interleukin-1 levels in one- and two-stage surgical procedures: a randomized prospective trial

Objective: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1 levels in one- and two-stage surgical procedures.Materials and methods: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II). All clinical periodontal parameters were recorded; peri-implant crevicular fluid (PICF) samples were collected before loading (T0) and during the third (T1) and sixth (T2) months after loading. ABLR values were evaluated at T0 and T2 by using dental tomography. PICF was analysed after T2 samples were collected. The study was registered through clinicaltrials.gov; identifier NCT03045458.Results: This study found that, the probing pocket depth was found to be significantly higher in Group I than Group II at both T1 and T2 (p<.05). There was no significant difference in other clinical parameters between the groups (p>.05). There was a significant difference between Group I ABLR values at T0 and T2 (p<.05). The PICF IL-1 levels were not significantly different between groups (p>.05).Conclusions: Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.