New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

被引：16

作者：

Roy, Prodip K. ^{[1
]}

Ashimine, Runa ^{[1
]}

Miyazato, Haruna ^{[2
]}

Taira, Junsei ^{[2
]}

Ueda, Katsuhiro ^{[1
]}

机构：

[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, 1 Senbaru, Nishihara, Okinawa 9032013, Japan

[2] Okinawa Natl Coll Technol, Dept Bioresources Engn, 905 Henoko, Nago, Okinawa 9052192, Japan

来源：

MOLECULES | 2016年 / 21卷 / 05期

关键词：

casbane; cembrane; antibacterial; cytotoxicity; HCT; 116; cells; anti-inflammatory; CESPITULARIA SP; CYTOTOXIC CEMBRANOLIDES; ALCYONOLIDE CONGENERS; MICHAELAE; CRASSUM; DURUM;

D O I：

10.3390/molecules21050679

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4-7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/ IFN-gamma-stimulated RAW 264.7 macrophage cells.

引用

页数：9

共 50 条

[1] Antitumor Cembrane Diterpenoids from the South China Sea Soft Coral Lobophytum sp.
Song, Yu-Ting
Yu, Dan-Dan
Zhi Su, Ming
Luo, Hui
Cao, Jian-Guo
Yao, Li-Gong
Liang, Lin-Fu
Guo, Yue-Wei
Yang, Fan
CHEMISTRY & BIODIVERSITY, 2023, 20 (04)
[2] NEW CEMBRANE-TYPE DITERPENOIDS FROM THE OKINAWAN SOFT CORAL SINULARIA SP
IGUCHI, K
SHIMURA, H
YAMADA, Y
JOURNAL OF NATURAL PRODUCTS, 1992, 55 (12): : 1779 - 1782
[3] New Marine Diterpenoid from the Okinawan Soft Coral, Lobophytum sp.
Sato, Kosuke
Ishigami, Shinnosuke
Koike, Masaki
Takegahara, Haruto
Yamamoto, Ayumi
Kaneko, Kensuke
Tani, Kazuki
Ishii, Takahiro
Kamada, Takashi
NATURAL PRODUCT COMMUNICATIONS, 2023, 18 (01)
[4] New cytotoxic cembranolides from an Okinawan soft coral, Lobophytum sp.
Roy, Prodip K.
Roy, Sona
Ueda, Katsuhiro
FITOTERAPIA, 2019, 136
[5] Four New Cembrane Diterpenes from the Hainan Soft Coral Lobophytum sp.
Chen Si-Han
Huang Hui
Guo Yue-Wei
CHINESE JOURNAL OF CHEMISTRY, 2008, 26 (12) : 2223 - 2227
[6] New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.
Yang, Bin
Zhou, Xuefeng
Huang, Hui
Yang, Xian-Wen
Liu, Juan
Lin, Xiuping
Li, Xiubao
Peng, Yan
Liu, Yonghong
MARINE DRUGS, 2012, 10 (09): : 2023 - 2032
[7] Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
Roy, Prodip K.
Maarisit, Wilmar
Roy, Michael C.
Taira, Junsei
Ueda, Katsuhiro
MARINE DRUGS, 2012, 10 (12): : 2741 - 2748
[8] New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.
Yin, Jian
Zhao, Min
Ma, Minshan
Xu, Yuping
Xiang, Zheng
Cai, Yuepiao
Dong, Jianyong
Lei, Xinxiang
Huang, Kexin
Yan, Pengcheng
MARINE DRUGS, 2013, 11 (02): : 455 - 465
[9] New marine cembrane-type diterpenoids from the Okinawan soft coral Clavularia koellikeri
Iwashima, M
Matsumoto, Y
Takahashi, H
Iguchi, K
JOURNAL OF NATURAL PRODUCTS, 2000, 63 (12): : 1647 - 1652
[10] Two new cembrane-type diterpenoids from Okinawan soft coral of the genus, Sarcophyton
Miyaoka, H
Taira, S
Mitome, H
Iguchi, K
Matsumoto, K
Yokoo, C
Yamada, Y
CHEMISTRY LETTERS, 1996, (03) : 239 - 240

← 1 2 3 4 5 →