Flavonoids: An alternative pathway for the treatment of Alzheimer's disease

Alzheimer's is a non-curative disease that occurs in most of the geriatric patients worldwide. It is one of the top 10 diseases which lead to mortality. According to Indian statistics 2020, the average age for symptoms to occur in Alzheimer's is 66-68 years. Patients can survive up to 8 years after the symptoms of dementia. Women are predominant than men. As there is no permanent treatment for Alzheimer's, but medication and management strategies may temporarily improve. On the basis of clinical trials, it can be suggested that single herbs may offer complementary benefits to the approved drugs. Flavonoids are used prophylactically to treat Alzheimer's, as flavonoids are present in most of the fruits, vegetables, and other daily essential products like apple, berries, spinach, red cabbage, onion, dark chocolate, green tea, etc. Flavonoids are also used to treat early symptoms of Alzheimer's like learning and memory loss as flavonoids cross blood-brain barrier (BBB) and prevent tangles. Natural flavonoids mainly possess antioxidant and neuroprotective action which helps to restore damaged brain cells up to a certain extent. Myricetin, morin. rutin, quercetin, fisetin, ginkgo biloba extract, genistein, kaempferol, apigenin, anthocyanin, glycitein are some of the flavonoids used in prevention of Alzheimer's disease. In present study, we discuss different flavonoids to prevent and treat symptoms that are associated with Alzheimer's disease.