Family-based study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence

被引：32

作者：

Grzywacz, Anna ^{[1
]}

Samochowiec, Agnieszka ^{[1
,2
]}

Ciechanowicz, Andrzej ^{[3
]}

Samochowiec, Jerzy ^{[1
]}

机构：

[1] Pomeranian Med Univ, Dept Psychiat, PL-71460 Szczecin, Poland

[2] Univ Szczecin, Interdept Unit Pedag Educ, PL-71062 Szczecin, Poland

[3] Pomeranian Med Univ, Dept Lab Diagnost & Mol Med, PL-70111 Szczecin, Poland

来源：

PHARMACOLOGICAL REPORTS | 2010年 / 62卷 / 05期

关键词：

BDNF; gene; alcohol dependence; TDT (transmission disequilibrium test); trios; family; VAL66MET POLYMORPHISM; ASSOCIATION;

D O I：

10.1016/S1734-1140(10)70354-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related to the nerve growth factor family, which are responsible for the proliferation, survival and differentiation of neurons. BDNF is thought to be involved in the pathogenesis of bipolar disorder, schizophrenia, eating disorders and addiction. We hypothesize that a functionally relevant polymorphism of the BDNF gene promoter may be associated with the pathogenesis of alcohol dependence. We performed an association study of 141 families with alcohol dependence. One hundred and thirty-eight healthy control subjects were matched based on ethnicity and gender. An association between the BDNF Va166Met gene polymorphism and alcoholism was not found.

引用

页码：938 / 941

页数：4

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