The use of plants as biofactories for the production of medical products and vaccines has a long history, but the recent COVID-19 pandemic has caused this set of technologies, for their potential to contribute to the development of innovative solutions for tackling pandemic spread worldwide, to rise in prominence. The purpose of this paper is to analyze the global innovation scenario of plant-based vaccine production. Methods: Patent search using a specific set of technical classification codes and keywords was performed using the Questel-Orbit database, with a final output of 180 patent families, corresponding to 1397 single patents. Results: Plant-based vaccines production is an innovation sector with positive development especially in the last five-year period (30% growth). Fifty percent of the patents were registered in the United States, standing out as the most attractive patent system worldwide. The inventive activity was led by private firms owning the 49% of the patent families, and the key-players group includes the companies that successfully developed plant-based COVID-19 vaccine candidates, indicating a strong connection between the expertise in innovation production and the capacity to adapt inventions to the current pandemic vaccine demand. Virus-like particles technology has increased in importance over the past few years. Conclusion: Patent data confirm their relevant role as indicators of innovation and technological evolution. Plant-based vaccines are expected to acquire an increasing role over the next few years as the current pandemic acts as an innovation catalyst.
机构:
Good Food Inst, Sci & Technol, 1380 Monroe St NW,229, Washington, DC 20010 USAGood Food Inst, Sci & Technol, 1380 Monroe St NW,229, Washington, DC 20010 USA
Clayton, Erin M. Rees
Weston, Zak
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Good Food Inst, 1380 Monroe St NW,229, Washington, DC 20010 USAGood Food Inst, Sci & Technol, 1380 Monroe St NW,229, Washington, DC 20010 USA
机构:
Univ Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, MexicoUniv Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, Mexico
Rosales-Mendoza, Sergio
Orellana-Escobedo, Lucia
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Univ Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, MexicoUniv Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, Mexico
Orellana-Escobedo, Lucia
Romero-Maldonado, Andrea
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Univ Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, MexicoUniv Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, Mexico
Romero-Maldonado, Andrea
Decker, Eva L.
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Univ Freiburg, Fac Biol, D-79104 Freiburg, GermanyUniv Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, Mexico
Decker, Eva L.
Reski, Ralf
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机构:
Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany
BIOSS Ctr Biol Signalling Res, Freiburg, Germany
FRIAS Freiburg Inst Adv Studies, Freiburg, GermanyUniv Autonoma San Luis Potosi, Fac Ciencias Quim, Lab Biofarmaceut Recombinantes, San Luis Potosi 78210, Slp, Mexico
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Univ Sao Paulo, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
Cesar, Francine C. S.
Carnevale Neto, Fausto
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Univ Sao Paulo, Dept Fis & Quim, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
Carnevale Neto, Fausto
Porto, Geciane S.
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Univ Sao Paulo, Fac Econ & Adm, BR-14040905 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
Porto, Geciane S.
Maia Campos, Patricia M. B. G.
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Univ Sao Paulo, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil