Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

被引：45
|
作者：
Patil, Nitin A. [1 ,2 ]
Tailhades, Julien [1 ]
Hughes, Richard Anthony [3 ]
Separovic, Frances [2 ]
Wade, John D. [1 ,2 ,4 ,5 ]
Hossain, Mohammed Akhter [1 ,2 ,4 ,5 ]
机构：
[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
[3] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic 3010, Australia
[4] Univ Melbourne, Florey Dept Neurosci, Melbourne, Vic 3010, Australia
[5] Univ Melbourne, Florey Dept Mental Hlth, Melbourne, Vic 3010, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 01期
基金：
澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
bioactive peptides; disulfide bonds; peptide and protein folding; oxidative folding; recombinant technology; K EPOXIDE REDUCTASE; SINGLE-CHAIN FV; ESCHERICHIA-COLI; INTERMEMBRANE SPACE; CRYSTAL-STRUCTURE; RESPIRATORY-CHAIN; PHOTOSYSTEM-II; FUSION PROTEIN; RELAY SYSTEM; BACTERIAL HOMOLOG;
D O I：
10.3390/ijms16011791
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioactive peptides play important roles in metabolic regulation and modulation and many are used as therapeutics. These peptides often possess disulfide bonds, which are important for their structure, function and stability. A systematic network of enzymes-a disulfide bond generating enzyme, a disulfide bond donor enzyme and a redox cofactor-that function inside the cell dictates the formation and maintenance of disulfide bonds. The main pathways that catalyze disulfide bond formation in peptides and proteins in prokaryotes and eukaryotes are remarkably similar and share several mechanistic features. This review summarizes the formation of disulfide bonds in peptides and proteins by cellular and recombinant machinery.
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页码：1791 / 1805
页数：15
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