Inhibitory effect of carboxymethylpachymaran on cyclophosphamide-induced oxidative stress in mice

被引：49
|
作者：
Wei, Xiao-Jie [1 ]
Hu, Ting-Jun [1 ]
Chen, Jiong-Ran [2 ]
Wei, Ying-Yi [1 ]
机构：
[1] Guangxi Univ, Coll Anim Sci & Technol, Nanning 530005, Peoples R China
[2] Chinese Acad Agr Sci, Lanzhou Inst Anim & Vet Pharmaceut, Lanzhou 730050, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2011年 / 49卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Carboxymethylpachymaran; Immunity; Oxidative stress; Cyclophosphamide; PORIA-COCOS; ANTIINFLAMMATORY ACTIVITY; ANTITUMOR POLYSACCHARIDE; ANTIOXIDANT ACTIVITY; PROPHYLACTIC ACTION; ACID; EXPRESSION; SUSCEPTIBILITY; PROTECTION; DISORDERS;
D O I：
10.1016/j.ijbiomac.2011.07.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of the present study was to investigate the immunomodulatory effect and antioxidant activity of carboxymethylpachymaran on cyclophosphamide-induced immunosuppression in mice in vivo. The results showed that carboxymethylpachymaran could be used to overcome the cyclophosphamide-induced immunosuppression in mice. Moreover, it significantly increased the thymus and spleen indices, lysozyme, catalase and superoxidase dismutase activities, and total antioxidant capacity. In contrast, it decreased xanthine oxidase activity and malondialdehyde levels. The results indicated that carboxymethylpachymaran might play an important role in the prevention of oxidative damage in the immunological system. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：801 / 805
页数：5
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