Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates

被引：266
|
作者：
Betancort, JM
Sakthivel, K
Thayumanavan, R
Barbas, CF
机构：
[1] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 27期
基金：
美国国家卫生研究院;
关键词：
asymmetric catalyst; asymmetric synthesis; Michael reaction;
D O I：
10.1016/S0040-4039(01)00793-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselective direct Michael additions of ketones using (S)-1-(2-pyrroldinylmethyl)-pyrrolidine as a catalyst are described. Michael adducts with up to 91% e.e. were obtained by the reaction of alkylidene malonates with simple unactivated ketones under mild reaction conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4441 / 4444
页数：4
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