An Overview on Indole Aryl Sulfide/Sulfone (IAS) as Anti-HIV Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

被引：13
|
作者：
Sinha, Arun K. [1 ,2 ,3 ]
Equbal, Danish [1 ,4 ]
Rastogi, Sumit K. [1 ,2 ]
Kumar, Santosh [1 ,2 ]
Kumar, Ravindra [1 ,2 ]
机构：
[1] CSIR, Med & Proc Chem Div, Cent Drug Res Inst, Sect 10,Sitapur Rd, Lucknow 22603, Uttar Pradesh, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
[3] Kolhan Univ Chaibasa, Chaibasa 833201, Jharkhand, India
[4] Sai Life Sci Ltd, Proc R&D, Hyderabad 500010, Telangana, India
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 04期
关键词：
Arbidol; Indolearylsulfone; NNRTIs; Structure Activity Relationship (SAR); HUMAN-IMMUNODEFICIENCY-VIRUS; TUBULIN POLYMERIZATION; BIOLOGICAL EVALUATION; HIGHLY POTENT; WILD-TYPE; INDOLYLARYLSULFONES; DERIVATIVES; SULFONES; DESIGN; DISCOVERY;
D O I：
10.1002/ajoc.202100744
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Sulfur-containing indoles are widely studied against different biological targets. Among several potential drug candidates, seven molecules of this class are in the current market and a few of them are either in pipeline or in different stages of clinical trials. Particularly, arylthioindoles or indolylarylsulfones (IAS) received great attention by medicinal chemists due to their pharmokinetic profiles and wide spectrum of biological activities like antiviral, anticancer, cardiovascular, and antibacterial properties. This review summarizes the developmental process, synthesis and structure activity relationship (SAR) around arylthioindole/indolylaryl sulfone scaffolds for antiviral/anti-HIV non-nucleoside reverse transcriptase inhibitor (NNRTIs) activities. It also offers perspective for further development of 3-indolylarylsulfones as an anti-viral agent including their potential against novel COVID-19 infection.
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页数：12
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