Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women

被引:24
作者
Liu, Lei [1 ]
Hu, Jiajin [1 ,2 ]
Yang, Liu [3 ]
Wang, Ningning [4 ]
Liu, Yang [1 ]
Wei, Xiaotong [5 ]
Gao, Ming [5 ]
Wang, Yinuo [1 ]
Ma, Yanan [5 ]
Wen, Deliang [1 ,2 ]
机构
[1] China Med Univ, Inst Hlth Sci, Shenyang 110122, Liaoning, Peoples R China
[2] China Med Univ, Res Ctr China Med Univ Birth Cohort, Shenyang 110122, Liaoning, Peoples R China
[3] Shenyang Matern & Child Hlth Hosp, Dept Obstet & Gynecol, Shenyang 110122, Liaoning, Peoples R China
[4] Dalian Med Univ, Sch Publ Hlth, Dalian 116044, Liaoning, Peoples R China
[5] China Med Univ, Sch Publ Hlth, Shenyang 110122, Liaoning, Peoples R China
关键词
BODY-MASS INDEX; WNT SIGNALING PATHWAY; MATERNAL OBESITY; HEALTH; INFLAMMATION; INSIGHTS; OUTCOMES;
D O I
10.1155/2020/4934206
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background. Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepregnancy overweight/obesity and GDM and at clarifying the relationship between the WISP1 level and clinical cardiometabolic parameters. Methods. A total of 313 participants were screened from a multicenter prospective prebirth cohort: Born in Shenyang Cohort Study (BISCS). Subjects were examined with a 2x2 factorial design for body mass index BMI >= 24 and GDM. Between 24 and 28 weeks of pregnancy, follow-up individuals underwent an OGTT and blood sampling for cardiometabolic characterization. Results. We observed that the WISP1 levels were elevated in prepregnancy overweight/obesity patients with GDM, compared with nonoverweight subjects with normal blood glucose (3.45 +/- 0.89 vs. 2.91 +/- 0.75 ng/mL). Multilogistic regression analyses after adjustments for potential confounding factors revealed that WISP1 was a strong and independent risk factor for prepregnancy overweight/obesity with GDM (all ORs>1). In addition, the results of the ROC analysis indicated that WISP1 exhibited the capability to identify individuals with prepregnancy overweight/obesity and GDM (all AUC>0.5). Finally, univariate and multivariate linear regression showed that WISP1 level was positively and independently correlated with fasting blood glucose, systolic blood pressure, and aspartate aminotransferase and was negatively correlated with HDL-C and complement C1q. Conclusions. WISP1 may be critical for the prediction, diagnosis, and therapeutic strategies against obesity and GDM in pregnant women.
引用
收藏
页数:10
相关论文
共 42 条
  • [2] Barchetta I, 2017, J ENDOCR SOC, V1, P660, DOI 10.1210/js.2017-00108
  • [3] WNT1 inducible signaling pathway protein 1 (WISP1): A novel mediator linking development and disease
    Berschneider, Barbara
    Koenigshoff, Melanie
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2011, 43 (03) : 306 - 309
  • [4] Mammalian target of rapamycin signaling in diabetic cardiovascular disease
    Chong, Zhao Zhong
    Maiese, Kenneth
    [J]. CARDIOVASCULAR DIABETOLOGY, 2012, 11
  • [5] Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010
    Flegal, Katherine M.
    Carroll, Margaret D.
    Kit, Brian K.
    Ogden, Cynthia L.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (05): : 491 - 497
  • [6] The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes
    Hoerbeit, Tina
    Tacke, Christopher
    Markova, Mariya
    de Wiza, Daniella Herzfeld
    Van de Velde, Frederique
    Bekaert, Marlies
    Van Nieuwenhove, Yves
    Hornemann, Silke
    Roediger, Maria
    Seebeck, Nicole
    Fried, Elisabeth
    Jonas, Wenke
    Thoresen, G. Hege
    Kuss, Oliver
    Rosenthal, Anke
    Lange, Volker
    Pfeiffer, Andreas F. H.
    Schuermann, Annette
    Lapauw, Bruno
    Rudovich, Natalia
    Pivovarova, Olga
    Ouwens, D. Margriet
    [J]. DIABETOLOGIA, 2018, 61 (09) : 2054 - 2065
  • [7] Association of Total and Trimester-Specific Gestational Weight Gain Rate with Early Infancy Weight Status: A Prospective Birth Cohort Study in China
    Hu, Jiajin
    Aris, Izzuddin M.
    Oken, Emily
    Ma, Yanan
    Ding, Ning
    Gao, Ming
    Wei, Xiaotong
    Wen, Deliang
    [J]. NUTRIENTS, 2019, 11 (02)
  • [8] A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank
    Hypponen, Elina
    Mulugeta, Anwar
    Zhou, Ang
    Santhanakrishnan, Vimaleswaran Karani
    [J]. LANCET DIGITAL HEALTH, 2019, 1 (03): : E116 - E126
  • [9] The tumor cell-secreted matricellular protein WISP1 drives pro-metastatic collagen linearization
    Jia, Hong
    Janjanam, Jagadeesh
    Wu, Sharon C.
    Wang, Ruishan
    Pano, Glendin
    Celestine, Marina
    Martinot, Ophelie
    Breeze-Jones, Hannah
    Clayton, Georgia
    Garcin, Cecile
    Shirinifard, Abbas
    Zaske, Ana Maria
    Finkelstein, David
    Labelle, Myriam
    [J]. EMBO JOURNAL, 2019, 38 (16)
  • [10] WISP1 promotes non-alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling
    Jung, Tae Woo
    Kang, Changmuk
    Goh, Jiwon
    Chae, Soo In
    Kim, Hyoung-Chun
    Lee, Tae Jin
    Abd El-Aty, A. M.
    Jeong, Ji Hoon
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (08) : 6077 - 6087