Design and engineering of artificial oxygen-activating metalloenzymes

被引：140

作者：

Nastri, Flavia ^{[1
]}

Chino, Marco ^{[1
]}

Maglio, Ornella ^{[1
,2
]}

Bhagi-Damodaran, Ambika ^{[3
]}

Lu, Yi ^{[3
]}

Lombardi, Angela ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Chem Sci, Via Cintia, I-80126 Naples, Italy

[2] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy

[3] Univ Illinois, Dept Chem, A322 CLSL,600 South Mathews Ave, Urbana, IL 61801 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2016年 / 45卷 / 18期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DE-NOVO DESIGN; CYTOCHROME-C PEROXIDASE; UNNATURAL AMINO-ACIDS; CARBOXY-SUBSTITUTED TETRAARYLPORPHYRIN; HEME OCTAPEPTIDE MICROPEROXIDASE-8; PSEUDOMONAS-AERUGINOSA AZURIN; NONHEME IRON ENZYMES; 2-HIS-1-CARBOXYLATE FACIAL TRIAD; BIOTIN-STREPTAVIDIN TECHNOLOGY; METAL-ORGANIC FRAMEWORKS;

D O I：

10.1039/c5cs00923e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design approaches has produced many metal-containing biocatalysts able to adopt the functions of native enzymes or even novel functions beyond those found in Nature.

引用

页码：5020 / 5054

页数：35

共 50 条

[1] Recent achievments in the design and engineering of artificial metalloenzymes
Duerrenberger, Marc
Ward, Thomas R.
CURRENT OPINION IN CHEMICAL BIOLOGY, 2014, 19 : 99 - 106
[2] MANGANESE COMPLEXES AS OXYGEN-ACTIVATING AGENTS
MINOR, JL
RICHENS, DT
SAWYER, DT
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1980, 180 (AUG): : 7 - CELL
[3] Assembly of an oxygen-activating heterodinuclear manganese/iron cofactor
Griese, J. J.
Graslund, A.
Hogbom, M.
Roos, K.
Siegbahn, P. E.
Cox, N.
Shafaat, H. S.
Lubitz, W.
Branca, R. M.
Lehtio, J.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 : S278 - S278
[4] Design of artificial metalloenzymes
Thomas, CM
Ward, TR
APPLIED ORGANOMETALLIC CHEMISTRY, 2005, 19 (01) : 35 - 39
[5] Oxygen-activating nickel(II) complexes with bulky oximate ligands
Young, Alyssa L.
Davis, Craig M.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[6] Cytochrome p450, the oxygen-activating enzyme in xenobiotic metabolism
Snyder, R
TOXICOLOGICAL SCIENCES, 2000, 58 (01) : 3 - 4
[7] BIOPHYSICAL DELINEATION OF OXYGEN-ACTIVATING ENZYMES OF DRUGS AND CARCINOGENIC COMPOUND METABOLISM
COOPER, DY
ROSENTHA.O
NARASIMH.S
OMURA, T
ESTABROO.RW
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1965, 192 (06): : 558 - &
[8] Structure, function and assembly of an oxygen-activating heterodinuclear Mn/Fe cofactor
Griese, Julia J.
Roos, Katarina
Cox, Nicholas
Shafaat, Hannah S.
Branca, Rui M. M.
Lehtio, Janne
Graslund, Astrid
Lubitz, Wolfgang
Siegbahn, Per E. M.
Hogbom, Martin
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 : S770 - S770
[9] Bioinspired Catalyst Design and Artificial Metalloenzymes
Deuss, Peter J.
den Heeten, Rene
Laan, Wouter
Kamer, Paul C. J.
CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (17) : 4680 - 4698
[10] Design strategies for the creation of artificial metalloenzymes
Heinisch, Tillmann
Ward, Thomas R.
CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (02) : 184 - 199

← 1 2 3 4 5 →