1,3-OXAZOLIDIN-5-ONES DERIVED FROM PROLINE AS CHIRAL COMPONENTS IN THE SYNTHESIS OF PREDICTIVE ENANTIOSELECTIVE COUPLING REAGENTS

被引：1

作者：

Kasperowicz-Frankowska, Katarzyna ^{[1
]}

Kolesinska, Beata ^{[1
]}

Gzik, Anna ^{[1
]}

Jastrzabek, Konrad ^{[1
]}

Kaminski, Zbigniew J. ^{[1
]}

机构：

[1] Lodz Univ Technol, Inst Organ Chem, Zeromskiego 116, PL-90924 Lodz, Poland

来源：

ACTA POLONIAE PHARMACEUTICA | 2018年 / 75卷 / 04期

关键词：

enantioselective condensation; triazine coupling reagent; peptide synthesis; diirality transfer to nitrogen; chiral nitrogen atom; AMINO-ACIDS; PEPTIDES; ESTER;

D O I：

10.32383/appdr/78726

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1,3-Oxazolid in-5-ones derived from both enantiomers of proline and trichloroacetaldehyde were prepared and applied as an amine component in the synthesis of chiral predictive triazine-based coupling reagents. The reagents were found to be useful in condensations yielding enantiomerically enriched products from racemic substrates.

引用

页码：921 / 927

页数：7

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