Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced by α2-adrenergic activation in the lateral parabrachial nucleus

被引：7
|
作者：
Andrade, C. A. F. [1 ]
De Oliveira, L. B. [2 ]
Andrade-Franze, G. M. F. [1 ]
De Luca, L. A., Jr. [1 ]
Colombari, Debora S. A. [1 ]
Menani, J. V. [1 ]
机构：
[1] UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
[2] Univ Fed Ouro Preto, Dept Biol Sci, DECBI NUPEB, Ouro Preto, MG, Brazil
来源：
BEHAVIOURAL BRAIN RESEARCH | 2015年 / 278卷
基金：
巴西圣保罗研究基金会;
关键词：
Sodium appetite; Adrenergic; GABA; Opioid; Dehydration; Thirst; SALT APPETITE; SODIUM APPETITE; SEROTONERGIC MECHANISMS; HYPERTONIC NACL; RAT; ANGIOTENSIN; DRINKING; CHOLECYSTOKININ; RESPONSES; THIRST;
D O I：
10.1016/j.bbr.2014.10.007
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Alpha(2)-adrenergic, gabaergic or opioidergic activation in the lateral parabrachial nucleus (LPBN) increases sodium intake. In the present study, we investigated the effects of single or combined blockade of opioidergic and gabaergic receptors in the LPBN on the increase of 0.3 M NaCl intake induced by alpha(2)-adrenoceptor activation in the LPBN. Male Holtzman rats (n = 5-9/group) with cannulas implanted bilaterally in the LPBN were treated with the diuretic furosemide (10 mg/kg b wt.) combined with low dose of the angiotensin converting enzyme inhibitor captopril (5 mg/kg b wt.) subcutaneously. Bilateral injections of moxonidine (alpha(2)-adrenergic/imidazoline receptor agonist, 0.5 nmol) into the LPBN increased furosemide + captopril-induced 0.3 M NaCl intake (25.8 +/- 1.4, vs. vehicle: 3.8 +/- 1.1 ml/60 min). The opioidergic receptor antagonist naloxone (100 nmol) or the GABA(A) receptor antagonist bicuculline (5 nmol) injected into the LPBN partially reduced the increase of 0.3 M NaCl intake produced by LPBN moxonidine (11.8 +/- 4.0 and 22.8 +/- 4.5, respectively, vs. vehicle+moxonidine: 31.6 +/- 4.0 ml/60 min, respectively). Similar to the treatment with each antagonist alone, the combined injections of naloxone (100 nmol) and bicuculline (5 nmol) into the LPBN also partially reduced moxonidine effects on 0.3 M NaCl intake (15.5 +/- 6.5 ml/60 min). The GABA(B) receptor antagonist saclofen (5 nmol) injected into the LPBN did not change the effects of moxonidine on 0.3 M NaCl intake (24.3 +/- 17.8 ml/120 min). These results suggest that the increase of 0.3 M NaCl intake by alpha(2)-adrenergic receptor activation in the LPBN is partially dependent on GABA(A) and opioid receptor activation in this area. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：535 / 541
页数：7
相关论文
共 32 条
  • [1] Activation of α2-adrenergic receptors into the lateral parabrachial nucleus enhances NaCl intake in rats
    Andrade, CAF
    Barbosa, SP
    De Luca, LA
    Menani, JV
    NEUROSCIENCE, 2004, 129 (01) : 25 - 34
  • [2] ANGIOTENSINERGIC AND CHOLINERGIC RECEPTORS OF THE SUBFORNICAL ORGAN MEDIATE SODIUM INTAKE INDUCED BY GABAergic ACTIVATION OF THE LATERAL PARABRACHIAL NUCLEUS
    Roncari, C. F.
    David, R. B.
    Johnson, R. F.
    De Paula, P. M.
    Colombari, D. S. A.
    De Luca, L. A.
    Johnson, A. K.
    Colombari, E.
    Menani, J. V.
    NEUROSCIENCE, 2014, 262 : 1 - 8
  • [3] IMPORTANCE OF CENTRAL AT1 RECEPTORS FOR SODIUM INTAKE INDUCED BY GABAERGIC ACTIVATION OF THE LATERAL PARABRACHIAL NUCLEUS
    Roncari, C. F.
    David, R. B.
    de Paula, P. M.
    Colombari, D. S. A.
    de Luca, L. A., Jr.
    Menani, J. V.
    NEUROSCIENCE, 2011, 196 : 147 - 152
  • [4] Involvement of central cholinergic mechanisms on sodium intake induced by gabaergic activation of the lateral parabrachial nucleus
    Asnar, Diego S.
    Roncari, Camila F.
    De Luca, Laurival A., Jr.
    de Paula, Patricia M.
    Colombari, Debora S. A.
    Menani, Jose V.
    NEUROSCIENCE LETTERS, 2013, 534 : 188 - 192
  • [5] Treatment with serotonergic 5HT2A/2C agonist inhibits NaCl intake induced by gabaergic activation of the lateral parabrachial nucleus
    de Oliveira, LB
    De Luca, LA
    Colombari, DSA
    Colombari, E
    Callera, JC
    Menani, JV
    FASEB JOURNAL, 2005, 19 (05): : A1649 - A1649
  • [6] Opioid activation in the lateral parabrachial nucleus induces hypertonic sodium intake
    De Oliveira, L. B.
    De Luca, L. A., Jr.
    Menani, J. V.
    NEUROSCIENCE, 2008, 155 (02) : 350 - 358
  • [7] Activation of serotonergic 5-HT1A receptors in the lateral parabrachial nucleus increases NaCl intake
    De Gobbi, JIF
    Barbosa, SP
    De Luca, LA
    Thunhorst, RL
    Johnson, AK
    Menani, JV
    BRAIN RESEARCH, 2005, 1066 (1-2) : 1 - 9
  • [8] Opioid and α2 adrenergic mechanisms are activated by GABA agonists in the lateral parabrachial nucleus to induce sodium intake
    De Oliveira, Lisandra B.
    Andrade, Carina A. F.
    De Luca, Laurival A., Jr.
    Colombari, Debora S. A.
    Menani, Jose V.
    BRAIN RESEARCH BULLETIN, 2018, 139 : 174 - 181
  • [9] GABAA receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake
    Callera, JC
    Oliveira, LB
    Barbosa, SP
    Colombari, DSA
    De Luca, LA
    Menani, JV
    NEUROSCIENCE, 2005, 134 (03) : 725 - 735
  • [10] Activation of GABAB receptors in the lateral parabrachial nucleus induces sodium intake in rats
    Callera, JC
    Barbosa, SP
    Colombari, DSD
    De Luca, LA
    Menani, JV
    FASEB JOURNAL, 2003, 17 (05): : A1210 - A1210
1234