A study of Parkinson's disease patients' serum using FTIR spectroscopy

被引：10
|
作者：
Wang, Xin [1 ]
Wu, Qipeng [1 ]
Li, Chao [2 ]
Zhou, Yuan [1 ]
Xu, Fangcheng [3 ]
Zong, Ling [1 ]
Ge, Shaolin [4 ]
机构：
[1] Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Hefei 230032, Anhui, Peoples R China
[4] China Tobacco Anhui Ind Co Ltd, Key Lab Tobacco Chem Anhui Prov, Hefei 230088, Anhui, Peoples R China
来源：
INFRARED PHYSICS & TECHNOLOGY | 2020年 / 106卷
基金：
中国国家自然科学基金;
关键词：
PD; FTIR spectroscopy; Serum; Early diagnosis; QUANTITATIVE CHANGES; MICROSPECTROSCOPY; PHOSPHOLIPIDS; DIFFERENTIATION; HIPPOCAMPUS; APOPTOSIS; TISSUES; PEOPLE; CELLS;
D O I：
10.1016/j.infrared.2020.103279
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Parkinson's disease (PD) threatens human beings' life and health largely, and early diagnosis of PD is important for its treatment. Fourier transform infrared (FTIR) spectroscopy can detect biomacromolecular changes in cells/tissues sensitively. In this study, we compared PD patients' and healthy persons' serum using FTIR spectroscopy and obtained the following results: 1. Significant differences were existed between peak-area ratios such as A3294/A3067, A1399/A1451 and A1243/A1313. 2. The protein secondary structure changed after PD occurred. 3. The combination of IR spectra and discriminant analysis could distinguish PD patients from healthy persons with 93.44% the sensitivity, 77.27% the specificity, 91.94% the accuracy and 89.16% the positive predictive value. These results suggest that FTIR spectroscopy may be a potentially helpful tool for early diagnosis of PD.
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页数：4
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