Bioactive glass-polymer materials for controlled release of ibuprofen

The ibuprofen (1B) release from samples composed by SiO2-CaO-P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8 h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different soaking periods in SBF demonstrates the growth of an apatite-like layer on the materials surface. The 113 release rate is related with the growth kinetics of this layer, that is slower when the materials do not contain the biodegradable polymer PLA. On the other hand, different 113 and/or glass contents do not affect the in vitro behavior of these materials. (C) 2003 Elsevier Science Ltd. All rights reserved.