Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice

被引：61

作者：

Tanaka, H

Park, CH

Ninomiya, A

Ozaki, H

Takada, A

Umemura, T

Kida, H ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Microbiol Lab, Sapporo, Hokkaido 0600818, Japan

[2] Hokkaido Univ, Grad Sch Vet Med, Dept Vet Clin Sci, Lab Comparat Pathol, Sapporo, Hokkaido 0600818, Japan

[3] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo 1088639, Japan

来源：

VETERINARY MICROBIOLOGY | 2003年 / 95卷 / 1-2期

关键词：

H5N1 influenza virus; pathogenicity for mouse; neurotropism; pneumotropism;

D O I：

10.1016/S0378-1135(03)00132-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The direct transmission of H5N1 influenza A viruses from chickens to humans in Hong Kong in 1997 emphasized the need to have information on the pathogenesis of avian influenza virus infection in mammals. H5N1 influenza viruses isolated from patients during the incident killed experimentally infected mice. The principal lesions of the mice were broncho-interstitial pneumonia and nonsuppurative encephalitis. Infectious viruses and/or viral antigens were detected in the brain as well as in the trigeminal and vagal ganglia but not in the blood of the mice. These findings suggest that the virus reached the brain through the vagus and/or trigeminal nerves following replication in the respiratory mucosa. The results imply that neurotropism of the H5N1 virus in mice is a novel characteristic in the pathogenesis of infection by human influenza virus isolates. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：1 / 13

页数：13

共 26 条

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