Lambert-Eaton syndrome with large-cell neuroendocrine carcinoma of the lung

被引：10
|
作者：
Grommes, Christian [1 ]
Preston, David C. [1 ]
Al-Kadhimi, Zaid [2 ,3 ]
Alshekhlee, Amer [1 ]
机构：
[1] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Neurol Inst, Cleveland, OH 44106 USA
[2] Wayne State Univ, Dept Oncol, Detroit, MI USA
[3] Wayne State Univ, Bone Marrow Transplant Ctr, Detroit, MI USA
来源：
MUSCLE & NERVE | 2008年 / 37卷 / 06期
关键词：
Lambert-Eaton; neuroendocrine carcinoma nerve conduction; repetitive nerve stimulation;
D O I：
10.1002/mus.21032
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Lambert-Eaton syndrome (LES) is an immune-mediated disorder of the presynaptic neuromuscular junction due to the blocking effect of the voltage-gated calcium channel (VGCC) antibodies. Small-cell lung cancer (SCLC) is the most common cause of LES. We report an unusual case of LES associated with large-cell neuroendocrine carcinoma (LCNEC) of the lung. In this case, clinical symptoms of LES predated the diagnosis of LCNEC by 6 years. After tumor resection, the patient experienced clinical and electrophysiological improvement. In addition, he had a decrease in VGCC antibody titer from 130 to 80 pmol/L. The onset of LES can be prolonged, and tumor surveillance should continue in these cases.
引用
收藏
页码：786 / 789
页数：4
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