Morphology of fibroblasts grown on substrates formed by dielectrophoretically aligned carbon nanotubes

被引：15
|
作者：
Yuen, Felix L. -Y. [2 ]
Zak, Gene [3 ]
Waldman, Stephen D. [1 ,2 ,3 ]
Docoslis, Aristides [1 ,2 ]
机构：
[1] Kingston Gen Hosp, Kingston, ON K7L 2V7, Canada
[2] Queens Univ, Dept Chem Engn, Kingston, ON K7L 3N6, Canada
[3] Queens Univ, Dept Mech & Mat Engn, Kingston, ON K7L 3N6, Canada
来源：
CYTOTECHNOLOGY | 2008年 / 56卷 / 01期
基金：
加拿大创新基金会;
关键词：
AC electrokinetics; carbon nanotube alignment; dielectrophoresis; microelectrodes; patterned substrate; tissue engineering;
D O I：
10.1007/s10616-007-9113-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Multiwall carbon nanotube templates formed on the surfaces of planar interdigitated microelectrode arrays by means of AC electric field-guided assembly are being explored as potential substrates for tissue engineering. The objective of the present study is to examine whether surface patterns of aligned multiwall carbon nanotubes can have an effect on cell growth, morphology, and alignment. Bovine fibroblasts grown on aligned carbon nanotubes for a period of 2 weeks were found to have raised bodies and pronounced cell extensions for anchoring themselves to the substrate similar to that of the cells found in native tissues. On the other hand, cells grown on various control surfaces had a flat, circular morphology. The cell cultures were visualized by means of SEM imaging and the resulting morphologies were statistically analyzed and compared.
引用
收藏
页码：9 / 17
页数：9
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