Autocrine activation of microglia by tumor necrosis factor-α

被引：178
|
作者：
Kuno, R [1 ]
Wang, JY [1 ]
Kawanokuchi, J [1 ]
Takeuchi, H [1 ]
Mizuno, T [1 ]
Suzumura, A [1 ]
机构：
[1] Nagoya Univ, Inst Environm Med, Dept Neuroimmunol, Chikusa Ku, Nagoya, Aichi 4648601, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 162卷 / 1-2期
关键词：
microglia; tumor necrosis factor-alpha (TNF-alpha); TNFR1(p55); TNFR2(p75);
D O I：
10.1016/j.jneuroim.2005.01.015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the central nervous system (CNS), tumor necrosis factor-alpha (TNF-alpha) derived from activated microglia plays a critical role as an inflammatory mediator. In this study, we examined the function of TNF-alpha as an autocrine mediator in microglial activation. TNF-alpha induced TNF-alpha production by microglia through ligation of TNF receptor 1 (TNFR1). TNF-alpha also increased the production of other inflammatory mediators. The activation of microglia by lipopolysaccharide is partially mediated by microglia-derived TNF-alpha. These findings suggest the existence of a positive feedback loop in the activation of microglia via TNF-alpha. This autocrine loop may be involved in the prolonged activation of microglia. (C) 2005 Elsevier B.V All rights reserved.
引用
收藏
页码：89 / 96
页数：8
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