Applanatumols A and B, meroterpenoids with unprecedented skeletons from Ganoderma applanatum

被引:41
|
作者
Luo, Qi [1 ,2 ]
Di, Lei [1 ]
Yang, Xiao-Hua [1 ,3 ]
Cheng, Yong-Xian [1 ]
机构
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
[2] Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China
[3] Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China
来源
RSC ADVANCES | 2016年 / 6卷 / 51期
基金
中国国家自然科学基金;
关键词
D O I
10.1039/c6ra05148k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Applanatumols A (1) and B [(+/-)-2], two unique meroterpenoids with a novel spiro[ benzofuran-2,2'-bicyclo [3.2.2]nonane] ring system and a naturally unusual dioxacyclopenta[cd]inden motif, respectively, were isolated from Ganoderma applanatum. Their structures were determined using spectroscopic data. In particular, the absolute configurations of 1 and 2 were assigned by X-ray diffraction analysis using the Flack parameter and ECD calculations, respectively. A plausible biosynthetic pathway for 1 and 2 is proposed. The biological activities of 1 and 2 against renal fibrosis were accessed in rat proximal tubular epithelial cells.
引用
收藏
页码:45963 / 45967
页数:5
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