Synthesis and characterization of s-triazine based 1,5-benzothiazepines and isoxazoles

Series of compounds 2,4-bis-phenylamino-6-[4'-{2 ''-(substituted phenyl/cinnamyl/2"'-furanyl/2"'-thienyl)-2",3 '' dihydro-1 '',5 ''-benzothiazepine-4 ''-yl}phenyl amino]-s-triazine 7(a-f) were prepared by reaction of different chalcones and 2-amino thiophenol in the presence of glacial acetic acid. Chalcones 6(a-f) on cyclisation with hydroxylamine hydrochloride in the presence of alkali gave 2,4-bis-phenylamino-6-[4'-{5 ''-(substituted phenyl/Cinnamyl/2"'-furanyl/2"'-thienyl)-2 ''-isoxazol-3 ''-yl}phenyl amino/-s-triazine 8(a-f). The products were characterized by elemental analysis, IR and (1)H NMR data. All the synthesized compounds have been evaluated for their in vitro antibacterial activity against four different strain viz. S. aurens (MTCC-96), B. subtilis (MTCC-441) (Gram-positive bacteria) and E. coli (MTCC-443), S. paratyphi-B (MTCC-733) (Gram-negative bacteria) by agar diffusion method.