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Guangzhou Med Univ, Guangzhou Inst Resp Hlth,Pulm & Critical Care Med, Natl Clin Res Ctr Resp Dis,State Key Lab Resp Dis, Natl Ctr Resp Med,Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China Guangzhou Med Univ, Guangzhou Inst Resp Hlth,Pulm & Critical Care Med, Natl Clin Res Ctr Resp Dis,State Key Lab Resp Dis, Natl Ctr Resp Med,Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China