Organocatalytic asymmetric Michael addition of 2,4-pentandione to nitroolefins

被引：247
|
作者：
Wang, J [1 ]
Li, H
Duan, WH
Zu, LS
Wang, W
机构：
[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 21期
关键词：
D O I：
10.1021/ol0519137
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel binaphthyl-derived amine thiourea organocatalyst has been developed and demonstrated to efficiently catalyze Michael addition reactions (using as low as 1 mol % loading) of diketones to nitroalkenes with remarkably high enantioselectivities.
引用
收藏
页码：4713 / 4716
页数：4
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