Metal-Free Mild Synthesis of Novel 1′H-Spiro[Cycloalkyl-1,2′-quinazolin]-4′(3′H)-ones by an Organocatalytic Cascade Reaction

被引：16

作者：

Ramesh, Rathinam ^{[1
]}

Kalisamy, Periyathambi ^{[1
]}

Malecki, Jan Grzegorz ^{[2
]}

Lalitha, Appaswami ^{[1
]}

机构：

[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India

[2] Univ Silesia, Dept Crystallog, Szkolna 9, PL-40006 Katowice, Poland

来源：

SYNLETT | 2018年 / 29卷 / 02期

关键词：

spiro compounds; quinazolinones; isatoic anhydride; amines; cycloalkanones; multicomponent reactions; TUBULIN POLYMERIZATION; NATURAL-PRODUCTS; FACILE ACCESS; DERIVATIVES; INHIBITORS; AGENTS; 5-ARYL-1,2,4-TRIAZOLIDINE-3-THIONES; QUINAZOLINE; CATALYST;

D O I：

10.1055/s-0036-1590917

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise organocatalytic method for the facile synthesis of some novel 1'H-spiro[cycloalkyl-1,2'-quinazolin]-4'(3'H)-ones via a one-pot, three-component condensation of isatoic anhydride, aryl or aliphatic amines and a cyclic ketone is described.

引用

页码：203 / 208

页数：6

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