New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity

被引：24

作者：

Li, Jia-Lin ^{[1
]}

Li, Na ^{[1
]}

Xing, Shan-Shan ^{[1
]}

Zhang, Nan ^{[2
]}

Li, Ban-Ban ^{[1
]}

Chen, Jian-Guang ^{[1
]}

Ahn, Jong-Seog ^{[3
]}

Cui, Long ^{[1
]}

机构：

[1] Beihua Univ, Coll Pharm, Jilin 132013, Jilin, Peoples R China

[2] Shenyang Med Coll, Affiliated Hosp 2, 20 Beijiu Rd, Shenyang 110000, Liaoning, Peoples R China

[3] KRIBB, Chem Biol Res Ctr, Chungbuk 363883, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2017年 / 40卷 / 11期

关键词：

Acanthopanax senticosus; Araliaceae; PTP1B; Neo-lignan; PTP1B; CONSTITUENTS; OBESITY; BARK;

D O I：

10.1007/s12272-015-0659-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2-8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50 value 15.2 +/- 1.4 A mu M.

引用

页码：1265 / 1270

页数：6

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