Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: Prototypes of pore-forming bacterial cytolysins

被引：249

作者：

Bhakdi, S

Bayley, H

Valeva, A

Walev, I

Walker, B

Weller, U

Kehoe, M

Palmer, M

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT MICROBIOL,NEWCASTLE TYNE NC2 4HN,TYNE & WEAR,ENGLAND

[2] WORCESTER FDN BIOMED RES,SHREWSBURY,MA 01545

来源：

ARCHIVES OF MICROBIOLOGY | 1996年 / 165卷 / 02期

关键词：

alpha-toxin; streptolysin-O; Escherichia coli hemolysin; transmembrane pores; microbial pathogenesis;

D O I：

10.1007/s002030050300

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin are well-studied prototypes of pore-forming bacterial cytotoxins. Each is produced as a water-soluble single-chain polypeptide that insets into target membranes to form aqueous transmembrane pores. This review will compare properties of the three toxin prototypes, highlighting the similarities and also the differences in their structure, mode of binding, mechanism of pore formation, and the responses they elicit in target cells. Pore-forming toxins represent the most potent and versatile weapons with which invading microbes damage the host macroorganism.

引用

页码：73 / 79

页数：7

共 45 条

[1]

Alouf J.E., 1991, SOURCEBOOK BACTERIAL, P147

[2] TRIGGERS AND SWITCHES IN A SELF-ASSEMBLING PORE-FORMING PROTEIN [J].