Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndrome

被引：17

作者：

Messerli, AW ^{[1
]}

Seshadri, N ^{[1
]}

Pearce, GL ^{[1
]}

Sachar, R ^{[1
]}

Hoogwerf, BJ ^{[1
]}

Sprecher, DL ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Prevent Cardiovasc Med, Cleveland, OH 44195 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 05期

关键词：

D O I：

10.1016/S0002-9149(03)00736-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We hypothesized that-the association of high sensitivity C-reactive protein (CRP) with urinary albumin excretion (UAE) is predominately mediated through its correlation with the metabolic syndrome. Serum CRP and urine albumin:creatinine ratios (ACR) from 720 preventive cardiology patients were analyzed to estimate age- and gender-adjusted relative risk of high CRP and metabolic syndrome for high ACR. These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction. (C) 2003 by Excerpta Medical, Inc.

引用

页码：610 / 612

页数：3

共 20 条

[1] [Anonymous], 2001, JAMA-J AM MED ASSOC, V285, P2846
[2] Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity
Arcaro, G
Zamboni, M
Rossi, L
Turcato, E
Covi, G
Armellini, F
Bosello, O
Lechi, A
[J]. INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (09) : 936 - 942
[3] Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance
Balletshofer, BM
Rittig, K
Enderle, MD
Volk, A
Maerker, E
Jacob, S
Matthaei, S
Rett, K
Häring, HU
[J]. CIRCULATION, 2000, 101 (15) : 1780 - 1784
[4] Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation
Bethin, KE
Vogt, SK
Muglia, LJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) : 9317 - 9322
[5] Novel clinical markers of vascular wall inflammation
Blake, GJ
Ridker, PM
[J]. CIRCULATION RESEARCH, 2001, 89 (09) : 763 - 771
[6] INTERLEUKIN-6 IS THE MAJOR REGULATOR OF ACUTE PHASE PROTEIN-SYNTHESIS IN ADULT HUMAN HEPATOCYTES
CASTELL, JV
GOMEZLECHON, MJ
DAVID, M
ANDUS, T
GEIGER, T
TRULLENQUE, R
FABRA, R
HEINRICH, PC
[J]. FEBS LETTERS, 1989, 242 (02) : 237 - 239
[7] Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease
Cleland, SJ
Sattar, N
Petrie, JR
Forouhi, NG
Elliott, HL
Connell, JMC
[J]. CLINICAL SCIENCE, 2000, 98 (05) : 531 - 535
[8] Feldt-Rasmussen B, 2000, DIABETES METAB, V26, P64
[9] Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects:: The Insulin Resistance Atherosclerosis Study
Festa, A
D'Agostino, R
Howard, G
Mykkänen, L
Tracy, RP
Haffner, SM
[J]. KIDNEY INTERNATIONAL, 2000, 58 (04) : 1703 - 1710
[10] Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease
Fichtlscherer, S
Rosenberger, G
Walter, DH
Breuer, S
Dimmeler, S
Zeiher, AM
[J]. CIRCULATION, 2000, 102 (09) : 1000 - 1006

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