N-(2-nitrophenyl)proline:: An intramolecular hydrogen bond forming reagent for the determination of the absolute configuration of primary amines

被引：18
|
作者：
Ahn, Hee Choon [1 ]
Choi, Kihang
机构：
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
[2] Korea Univ, Ctr Electro & Photo Respons Mol, Seoul 136701, South Korea
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 19期
关键词：
D O I：
10.1021/ol7017455
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-(2-Nitrophenyl)proline (2-NPP) amides of primary amines have a conformational preference for intramolecular hydrogen bonding. Because of the strong and selective anisotropic effects on the amine substituents, the absolute configuration of (X-chiral primary amines can be assigned by comparing the H-1 chemical shifts of diastereomeric 2-NPP amides.
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收藏
页码：3853 / 3855
页数：3
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