Strategies for treating oesophageal diseases with stem cells

被引:5
|
作者
Gao, Yang [1 ]
Jin, Shi-Zhu [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Gastroenterol & Hepatol, 246 Xuefu Rd, Harbin 150086, Heilongjiang, Peoples R China
来源
WORLD JOURNAL OF STEM CELLS | 2020年 / 12卷 / 06期
关键词
Stem cells; Oesophageal diseases; Differentiative capacity; Regenerative medicine; Tissue engineering; Gene therapy; ENDOSCOPIC SUBMUCOSAL DISSECTION; BONE-MARROW; MOLECULAR-MECHANISMS; CAUSTIC ESOPHAGITIS; ENDOTHELIAL-CELLS; TARGETED-DELIVERY; PROGENITOR CELLS; CARCINOMA CELLS; RISK-FACTORS; STRICTURE;
D O I
10.4252/wjsc.v12.i6.488
中图分类号
Q813 [细胞工程];
学科分类号
摘要
There is a wide range of oesophageal diseases, the most general of which are inflammation, injury and tumours, and treatment methods are constantly being developed and updated. With an increasingly comprehensive understanding of stem cells and their characteristics of multilineage differentiation, self-renewal and homing as well as the combination of stem cells with regenerative medicine, tissue engineering and gene therapy, stem cells are playing an important role in the treatment of a variety of diseases. Mesenchymal stem cells have many advantages and are most commonly applied; however, most of these applications have been in experimental studies, with few related clinical trials for comparison. Therefore, the methods, positive significance and limitations of stem cells in the treatment of oesophageal diseases remain incompletely understood. Thus, the purpose of this paper is to review the current literature and summarize the efficacy of stem cells in the treatment of oesophageal diseases, including oesophageal ulceration, acute radiation-induced oesophageal injury, corrosive oesophageal injury, oesophageal stricture formation after endoscopic submucosal dissection and oesophageal reconstruction, as well as gene therapy for oesophageal cancer.
引用
收藏
页码:488 / 499
页数:12
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