PIVOT-02: A phase 1/2, open-label, multicenter, dose escalation and dose expansion study of NKTR-214 and nivolumab in patients with select, locally advanced or metastatic solid tumor malignancies

被引：0

作者：

Diab, A. ^{[1
]}

Hurwitz, M. E. ^{[2
]}

Tannir, N. ^{[3
]}

Bernatchez, C. ^{[1
]}

Haymaker, C. ^{[1
]}

Bentebibel, S. E. ^{[1
]}

Curti, B. D. ^{[4
,5
]}

Wong, M. K. K. ^{[1
]}

Gergel, I. ^{[6
]}

Tagliaferri, M. ^{[7
]}

Zalevsky, J. ^{[8
]}

Hoch, U. ^{[9
]}

Aung, S. ^{[7
]}

Imperiale, M. ^{[7
]}

Cho, D. ^{[10
]}

Tykodi, S. S. ^{[11
,12
]}

Puzanov, I. ^{[13
]}

Kluger, H. ^{[14
]}

Hwu, P. ^{[1
]}

Sznol, M. ^{[15
]}

机构：

[1] MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX USA

[2] Yale Sch Med, Div Med Oncol, Dept Internal Med, New Haven, CT USA

[3] MD Anderson Canc Ctr, Genitourinary Med Oncol, Houston, TX USA

[4] Providence Canc Ctr, Dept Genitourinary Oncol Res, Portland, OR USA

[5] Earle A Chiles Res Inst, Portland, OR USA

[6] Nektar Therapeut, Dept Drug Dev, San Francisco, CA USA

[7] Nektar Therapeut, Dept Clin Dev, San Francisco, CA USA

[8] Nektar Therapeut, Dept Biol & Preclin Dev, San Francisco, CA USA

[9] Nektar Therapeut, Dept Clin Pharmacol, San Francisco, CA USA

[10] Dept Med Oncol, NYU Med Oncol Associates, New York, NY USA

[11] Univ Washington, Dept Med Oncol, Seattle, WA 98195 USA

[12] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[13] Roswell Pk Canc Inst, Dept Med Oncol, Buffalo, NY 14263 USA

[14] Yale Breast Ctr, Dept Med Oncol, New Haven, CT USA

[15] Yale Univ, Dept Med Oncol, Sch Med Med Oncol, New Haven, CT USA

来源：

ANNALS OF ONCOLOGY | 2017年 / 28卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1212TiP

引用

页数：2

共 50 条

[1] PIVOT-02: A phase 1/2, open-label, multicenter, dose escalation and dose expansion study of NKTR-214 and nivolumab in patients with select, locally advanced or metastatic solid tumor malignancies
Diab, A.
Hurwitz, M. E.
Tannir, N.
Bernatchez, C.
Haymaker, C.
Bentebibel, S. E.
Curti, B. D.
Wong, M. K. K.
Gergel, I.
Tagliaferri, M.
Zalevsky, J.
Hoch, U.
Aung, S.
Imperiale, M.
Cho, D.
Tykodi, S. S.
Puzanov, I.
Kluger, H.
Hwu, P.
Sznol, M.
ANNALS OF ONCOLOGY, 2017, 28
[2] PIVOT-02: Phase 1/2 Study of NKTR-214 and Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumor Malignancies
Papadimitrakopoulou, V.
Tannir, N.
Bernatchez, C.
Haymaker, C.
Bentebibel, S.
Curti, B.
Wong, M.
Gergel, I.
Tagliaferri, M.
Zalevsky, J.
Hoch, U.
Aung, S.
Imperiale, M.
Cho, D.
Tykodi, S.
Puzanov, I.
Kluger, H.
Hurwitz, M.
Hwu, P.
Sznol, M.
Diab, A.
JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S2152 - S2152
[3] Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)
Diab, Adi
Tannir, Nizar M.
Bentebibel, Salah-Eddine
Hwu, Patrick
Papadimitrakopoulou, Vassiliki
Haymaker, Cara
Kluger, Harriet M.
Gettinger, Scott N.
Sznol, Mario
Tykodi, Scott S.
Curti, Brendan D.
Tagliaferri, Mary A.
Zalevsky, Jonathan
Hannah, Alison L.
Hoch, Ute
Aung, Sandra
Fanton, Christie
Rizwan, Ahsan
Iacucci, Ernesto
Liao, Yijie
Bernatchez, Chantale
Hurwitz, Michael E.
Cho, Daniel C.
CANCER DISCOVERY, 2020, 10 (08) : 1158 - 1173
[4] REVEAL: A phase I/II, open-label, multicenter, dose escalation and dose expansion study of NKTR-262 [TLR 7/8 agonist] plus NKTR-214 [CD122-biased agonist] with or without nivolumab (nivo) in patients (pts) with locally advanced or metastatic solid tumor malignancies
Diab, A.
Marcondes, M.
Tagliaferri, M. A.
Hoch, U.
Zhang, J.
Rubas, W.
Kivimae, S.
Zalevsky, J.
Conley, A. P.
Borazanci, E.
D'Angelo, S. P.
ANNALS OF ONCOLOGY, 2018, 29
[5] Pivot-02: Preliminary safety, efficacy and biomarker results from the Phase 1/2 study of CD-122-biased agonist NKTR-214 plus nivolumab in patients with locally advanced/metastatic solid tumors
Diab, Adi
Tannir, Nizar
Cho, Daniel
Papadimitrakopoulou, Vali
Bernatchez, Chantale
Haymaker, Cara
Bentebibel, Salah Eddine
Curti, Brendan
Wong, Michael
Tykodi, Scott
Puzanoff, Igor
Smalberg, Ira
Gergel, Ivan
Tagliaferri, Mary
Zalevsky, Jonathan
Hoch, Ute
Aung, Sandra
Imperiale, Michael
Clemens, Wendy
Kluger, Harriet
Hurwitz, Michael
Hwu, Patrick
Sznol, Mario
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
[6] A phase 1/2 study of a novel IL-2 cytokine, NKTR-214, and nivolumab in patients with select locally advanced or metastatic solid tumors.
Diab, Adi
Tannir, Nizar M.
Bernatchez, Chantale
Haymaker, Cara L.
Bentebibel, Salah E.
Curti, Brendan D.
Wong, Michael K. K.
Gergel, Ivan
Tagliaferri, Mary Ann
Zalevsky, Jonathan
Hoch, Ute
Aung, Sandra
Imperiale, Michael
Cho, Daniel C.
Tykodi, Scott S.
Puzanov, Igor
Kluger, Harriet M.
Hurwitz, Michael E.
Hwu, Patrick
Sznol, Mario
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
[7] A PHASE 1, FIRST IN HUMAN, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY OF TST005 IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS
Chen, Lei
Tolcher, Anthony
Gabrail, Nashat
Barve, Minal
Wu, Xiaohua
Zhang, Jian
Shi, Michael
Qi, Chuan
Yu, Steven
Yao, Jenny
Wang, Jianming
Cavanaugh, Christopher
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A802 - A802
[8] A phase 1, first-in-human, open-label, dose escalation and dose expansion study of TST005 in patients with locally advanced or metastatic solid tumors
Tolcher, Anthony W.
Wu, Xiaohua
Zhang, Jian
Barve, Minal A.
Gabrail, Nashat Y.
Sommerhalder, David
Rivera, Ildefonso I. Rodriguez
Wilks, Sharon
Wu, Yong
Liu, Rujiao
Gao, Shuiping
Valiyil, Akhilkrishna
Sayi, Ntombizodwa
Germa, Caroline
Qi, Charlie
Chen, Lei
Yu, Steven
Yao, Jenny
Zhu, Xuelian
JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
[9] A phase 1b, open-label, dose escalation and expansion study of demcizumab plus pembrolizumab in patients with locally advanced or metastatic solid tumors
Johnson, Melissa
Rasco, Drew
Schneider, Brian
Shu, Catherine
Jotte, Robert
Parmer, Hema
Stagg, Robert
Lopez, Juanita
MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
[10] A Phase 1a/b Open-Label, Dose-Escalation Study of Etigilimab Alone or in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors
Mettu, Niharika B.
Ulahannan, Susanna, V
Bendell, Johanna C.
Garrido-Laguna, Ignacio
Strickler, John H.
Moore, Kathleen N.
Stagg, Robert
Kapoun, Ann M.
Faoro, Leonardo
Sharma, Sunil
CLINICAL CANCER RESEARCH, 2022, 28 (05) : 882 - 892

← 1 2 3 4 5 →