Effect of small molecule inhibitors of JAK2 kinase on modulating signaling cascades downstream of cytokine receptors

被引:0
|
作者
Olsen, Colin E. [1 ]
Gourley, Eric S. [1 ]
Liu, Xiao-Hui [1 ]
Walker, Jeff [1 ]
Grand, Cory L. [1 ]
Warner, Steven L. [1 ]
Vankayalapati, Hariprasad [1 ]
Bearss, David J. [1 ]
机构
[1] SuperGen Inc, Dublin, CA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:3592S / 3592S
页数:1
相关论文
共 50 条
  • [1] Jak2 is essential for signaling through a variety of cytokine receptors
    Parganas, E
    Wang, D
    Stravopodis, D
    Topham, DJ
    Marine, JC
    Teglund, S
    Vanin, EF
    Bodner, S
    Colamonici, OR
    van Deursen, JM
    Grosveld, G
    Ihle, JN
    CELL, 1998, 93 (03) : 385 - 395
  • [2] The Recent Medicinal Chemistry Development of Jak2 Tyrosine Kinase Small Molecule Inhibitors
    Baskin, R.
    Majumder, A.
    Sayeski, P. P.
    CURRENT MEDICINAL CHEMISTRY, 2010, 17 (36) : 4551 - 4558
  • [3] A novel small-molecule approach to inhibit Jak2 tyrosine kinase signaling
    Kapuria, Vaibhav
    Bartholomeusz, Geoffrey
    Kong, Ling-Yuan
    Bornman, William
    Peng, Zhenghong
    Pal, Ashutosh
    Maxwell, David
    Talpaz, Moshe
    Donato, Nicholas
    BLOOD, 2007, 110 (11) : 465A - 465A
  • [4] A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination
    Kapuria, Vaibhav
    Levitzki, Alexander
    Bornmann, William G.
    Maxwell, David
    Priebe, Waldemar
    Sorenson, Roderick J.
    Showalter, Hollis D.
    Talpaz, Moshe
    Donato, Nicholas J.
    CELLULAR SIGNALLING, 2011, 23 (12) : 2076 - 2085
  • [5] CRLF2/JAK Signaling Confers Susceptibility to JAK Inhibitors and Small Molecule Inhibitors of Protein Kinase C.
    West, C. Nathan
    Yoda, Akinori
    Chiaretti, Sabina
    Mani, Kartik
    Foa, Robin
    Bradner, James
    Weinstock, David M.
    BLOOD, 2009, 114 (22) : 1450 - 1450
  • [6] JAK2, the JAK2 V617F mutant and cytokine receptors
    Staerk, J.
    Kallin, A.
    Royer, Y.
    Diaconu, C. C.
    Dusa, A.
    Demoulin, J.-B.
    Vainchenker, W.
    Constantinescu, S. N.
    PATHOLOGIE BIOLOGIE, 2007, 55 (02): : 88 - 91
  • [7] THE IDENTIFICATION OF JAK2 TYROSINE KINASE AS A SIGNALING MOLECULE FOR GROWTH-HORMONE
    CARTERSU, C
    ARGETSINGER, LS
    CAMPBELL, GS
    WANG, XY
    IHLE, J
    WITTHUHN, B
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1994, 206 (03): : 210 - 215
  • [8] JAK2 kinase inhibitors and myeloproliferative disorders
    Chen, Andrew T.
    Prchal, Josef T.
    CURRENT OPINION IN HEMATOLOGY, 2010, 17 (02) : 110 - 116
  • [9] Modulation of JAK2 signaling pathways in vitro and in vivo by SGI-1252, a potent small molecule JAK2 inhibitor
    Olsen, C. E.
    Gourley, E. S.
    Liu, X.
    Vankayalapati, H.
    Vollmer, D.
    Severson, P.
    Bearss, J.
    Jones, C.
    Bearss, D. J.
    Warner, S. L.
    EJC SUPPLEMENTS, 2008, 6 (12): : 179 - 179
  • [10] Prolactin regulates actin cytoskeleton through JAK2 tyrosine kinase and JAK2 downstream targets
    Diakonova, Maria
    Rider, Leah
    Tao, Jing
    Suen, Diana
    ENDOCRINE JOURNAL, 2010, 57 : S350 - S350