In this article, via large-scale shaking table experiment, the dynamic response characteristics of different structural slopes when loading different frequency seismic waves and the relationship between different slope structures and the frequency characteristics of loading seismic waves are discussed. Results show: (1) When loading horizontal seismic waves, the hard rock slopes are more sensitive to relatively high frequency. The PGA magnification effect on the slope shoulder is more obvious. The obvious magnification of hard rock bedding slope appeared on 1/4 high of the slope, and of hard rock anti-dip slope appeared on the middle-upper part. (2) When loading vertical seismic waves, the slopes are more sensitive to relatively low frequency seismic waves. (3) When under the condition of low amplitude vibration, the PGA amplification coefficient has little relation to frequency, but when the vibration amplitude increases, the seismic wave frequency begins to show its influence on PGA amplification coefficient, which is more obvious on the middle-upper part of the slope. (4) When under horizontal vibration, the acceleration magnification effect of soft rock slope is more obvious than that of hard rock slope, and its obvious magnified part is closely associated with slope structure. (5) Bedding slopes have a more significant response to horizontal vibration, while anti-dip slopes are easier influenced by vertical vibration.