Quantiferon-TB-gold in tube test in the diagnosis of pulmonary and extra-pulmonary tuberculosis

被引：8

作者：

Garcia-Gasalla, Mercedes ^{[1
]}

Fernandez-Baca, Victoria ^{[2
]}

Mir-Viladrich, Isabel ^{[3
]}

Cifuentes-Luna, Carmen ^{[1
]}

Campins-Rosello, Antoni ^{[4
]}

Payeras-Cifre, Antoni ^{[1
]}

Serrano-Bujalance, Araceli ^{[1
]}

Ortiz-Monjo, Alicia ^{[1
]}

Pons-Vives, Salvador ^{[3
]}

Gallegos-Alvarez, Carmen ^{[2
]}

机构：

[1] Hosp Son Llatzer, Serv Med Interna, Palma de Mallorca, Mallorca, Spain

[2] Hosp Son Llatzer, Microbiol Serv, Palma de Mallorca, Mallorca, Spain

[3] Hosp Son Llatzer, Serv Neumol, Palma de Mallorca, Mallorca, Spain

[4] Hosp Son Dureta, Serv Med Interna Infecciosas, Palma de Mallorca, Mallorca, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2010年 / 28卷 / 10期

关键词：

Tuberculosis; QuantiFERON TB Gold test in Tube; TST; GAMMA RELEASE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; CLINICAL UTILITY; TB-2G TEST; SENSITIVITY; INFECTION; RESPONSES; ANTIGENS;

D O I：

10.1016/j.eimc.2010.01.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction The Interferon-gamma in vitro detection tests could be a useful tool in the diagnosis of active tuberculosis compared to Mycobacterium tuberculosis (MTB) Methods The QuantiFERON-TB-Gold in Tube (QFG-IT) test was performed on the blood of 118 patients with active tuberculosis and the results compared with the tuberculin test Results The QFG-IT test was positive in 94 cases (79 7%) negative in 17 (14 4%) and indeterminate in 7 (5 9%) A negative or indeterminate QFG-IT test was more common in older patients (P=0 017) and in cases with negative smear tests (P=0 041) The kappa agreement between the tuberculin and QFG-IT tests was 74 5% with a kappa value of 0 45 (SE 0 136) Thirteen of the patients studied were Infected with HIV and the tuberculin was positive in 5 of the 12 cases (38 5%) in whom it was performed with the QFG IT being positive in 9/13 (69 2%) Conclusions The QFG-IT test may be a useful complimentary tool to the tuberculin test in the diagnosis of tuberculosis (C) 2009 Elsevier Espana S L All rights reserved

引用

页码：685 / 689

页数：5

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