Aging Biomarkers: From Functional Tests to Multi-Omics Approaches

被引：45
|
作者：
Kudryashova, Ksenia S. [1 ]
Burka, Ksenia [1 ]
Kulaga, Anton Y. [1 ,2 ]
Vorobyeva, Nataliya S. [1 ]
Kennedy, Brian K. [3 ,4 ,5 ,6 ]
机构：
[1] Centaura AG, Bleicherweg 10, CH-8002 Zurich, Switzerland
[2] Romanian Acad, Syst Biol Aging Grp, Inst Biochem, Splaiul Independentei 296, Bucharest 060031, Romania
[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, 8 Med Dr,MD7, Singapore 117596, Singapore
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, 8 Med Dr,MD7, Singapore 117596, Singapore
[5] ASTAR, SICS, Brenner Ctr Mol Med, 30 Med Dr, Singapore 117609, Singapore
[6] Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA
来源：
PROTEOMICS | 2020年 / 20卷 / 5-6期
关键词：
aging; aging profiles; biological age; biomarkers; senescence; GENOME-WIDE ASSOCIATION; HUMAN LONGEVITY; TELOMERE LENGTH; OXIDATIVE STRESS; LIFE-SPAN; CONFIRMS APOE; END-PRODUCTS; MAJOR GENE; STEM-CELLS; ALL-CAUSE;
D O I：
10.1002/pmic.201900408
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging results in various deleterious changes in the human body that may lead to loss of function and the manifestation of chronic diseases. While diseases can generally be reliably diagnosed, the aging process itself requires more sophisticated approaches to evaluate its progression. Numerous attempts have been made to establish biomarkers to quantify human aging at the cellular, tissue, and organismal level. Here, an up-to-date overview of biomarkers related to human aging with an emphasis on biomarkers that take into account different mechanisms of aging between individuals is provided. Classical discrete molecular and non-molecular biomarkers handpicked by researches on the base of their strong correlation with age, as well as emerging omics-based biomarkers, are discussed and potential future directions and developments in the field of aging assessment are outlined.
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页数：15
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