Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight toss

被引：391

作者：

Balducci, S. ^{[1
,2
,3
]}

Zanuso, S. ^{[4
]}

Nicolucci, A. ^{[5
]}

Fernando, F. ^{[6
]}

Cavallo, S. ^{[7
,8
]}

Cardelli, P. ^{[7
,8
]}

Fallucca, S. ^{[7
,8
]}

Alessi, E. ^{[2
,3
]}

Letizia, C. ^{[9
,10
]}

Jimenez, A. ^{[11
]}

Fallucca, F. ^{[2
,3
]}

Pugliese, G. ^{[2
,3
]}

机构：

[1] Metab Fitness Assoc, I-00016 Rome, Italy

[2] Univ Roma La Sapienza, Div Diabet, St Andrea Hosp, Rome, Italy

[3] Univ Roma La Sapienza, Dept Clin Sci, Sch Med 2, Rome, Italy

[4] Univ Padua, Dept Motor Sci, Padua, Italy

[5] Consorzio Mario Negri Sud, Dept Clin Pharmacol & Epidemiol, Santa Maria Imbaro, Italy

[6] St Andrea Hosp, Div Sport Med, Rome, Italy

[7] Univ Roma La Sapienza, St Andrea Hosp, Clin Chem Lab, Rome, Italy

[8] Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, Sch Med 2, Rome, Italy

[9] Univ Roma La Sapienza, Policlin Umberto I, Div Internal Med, Rome, Italy

[10] Univ Roma La Sapienza, Sch Med 1, Dept Clin Sci, Rome, Italy

[11] European Univ Madrid, Phys Act & Sport Sci Coll, Madrid, Spain

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2010年 / 20卷 / 08期

关键词：

Type; 2; diabetes; Cardiovascular disease; Exercise; Inflammation; Insulin resistance; Physical fitness; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; INFLAMMATORY MARKERS; PHYSICAL-ACTIVITY; RISK; INTERVENTION; BIOMARKERS; MORTALITY; CYTOKINES; ADULTS;

D O I：

10.1016/j.numecd.2009.04.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: We investigated the effect of different exercise modalities on high sensitivity-C reactive protein (hs-CRP) and other inflammatory markers in patients with type 2 diabetes and the metabolic syndrome. Methods and results: Eighty-two patients were randomized into 4 groups: sedentary control (A); receiving counseling to perform low-intensity physical activity (B); performing prescribed and supervised high-intensity aerobic (C) or aerobic + resistance (D) exercise (with the same caloric expenditure) for 12 months. Evaluation of leisure-time physical activity and assessment of physical fitness, cardiovascular risk factors and inflammatory biomarkers was performed at baseline and every 3 months. Volume of physical activity increased and HbA(1c) decreased in Groups B-D. VO2max, HOMA-IR index, HDL-cholesterol, waist circumference and albuminuria improved in Groups C and D, whereas strength and flexibility improved only in Group D. Levels of hs-CRP decreased in all three exercising groups, but the reduction was significant only in Groups C and D, and particularly in Group D. Changes in VO2max and the exercise modalities were strong predictors of hs-CRP reduction, independent of body weight. Leptin, resistin and interleukin-6 decreased, whereas adiponectin increased in Groups C and D. Interleukin-1 beta, tumor necrosis factor-alpha and interferon-gamma decreased, whereas anti-inflammatory interleukin-4 and 10 increased only in Group D. Conclusion: Physical exercise in type 2 diabetic patients with the metabolic syndrome is associated with a significant reduction of hs-CRP and other inflammatory and insulin resistance biomarkers, independent of weight loss. Long-term high-intensity (preferably mixed) training, in addition to daytime physical activity, is required to obtain a significant anti-inflammatory effect. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：608 / 617

页数：10

共 30 条

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